盐酸小檗碱片联合二甲双胍治疗初发2型糖尿病的临床研究

Clinical study on berberine hydrochloride tablets combined with metformin in the treatment of primary type 2 diabetes

目的观察盐酸小檗碱片联合二甲双胍治疗初发2型糖尿病的临床疗效。方法将192例初发2型糖尿病患者随机分为治疗组和对照组,每组96例;对照组予二甲双胍治疗,治疗组在对照组基础上加盐酸小檗碱片治疗。两组疗程均为6个月,观察两组血糖(FBG、2 hPPG、HbA1c)、血脂(TC、LDL-C)、BMI、氧化应激产物(8-OHdG、MDA、SOD)、免疫细胞因子(TNF-α、IL-6)的变化情况,并分析HbA1c与氧化应激产物(8-OHdG、MDA、SOD)、免疫细胞因子(TNF-α、IL-6)之间的相关关系。结果两组治疗后,FBG、2 hPPG、HbA1c、TC、LDL-C、BMI、8-OHdG、MDA、TNF-α、IL-6均较治疗前明显下降(P<0.05),SOD明显升高(P<0.05);组间治疗后比较,治疗组各项指标均优于对照组(P<0.05),且8-OHdG与HbA1c呈正相关。结论盐酸小檗碱片联合二甲双胍能有效降低初发2型糖尿病患者的血糖、血脂、体质量,减轻患者氧化应激及炎症反应;8-OHdG有可能成为2型糖尿病治疗预后的评价指标。

Objective To observe the clinical effect of berberine hydrochloride tablets combined with metformin in the treatment of primary type 2 diabetes.Methods A total of 192 patients with primary type 2 diabetes were randomly divided into treatment group and control group,96 cases in each group;the control group was treated with metformin,and the treatment group was treated with berberine hydrochloride tablets and metformin.The course of treatment in both groups was 6 months.The changes of blood glucose(FBG,2 hPPG,HbA1 c),blood lipid(TC,LDL-C),BMI,oxidative stress products(8-OHdG,MDA,SOD),and immune cytokines(TNF-α,IL-6)were observed and the correlation between HbA1 c and oxidative stress products(8-OHdG,MDA,SOD),immune cytokines(TNF-α,IL-6)was analyzed.Results After treatment,the levels of FBG,2 hPPG,HbA1 c,TC,LDL-C,BMI,8-OHdG,MDA,TNF-α,IL-6 significantly decreased(P<0.05)and the level of SOD significantly increased(P<0.05)in both groups;after treatment,all indexes in the treatment group improved more significantly than those in the control group(P<0.05),and 8-OHdG was positively correlated with HbA1 c.Conclusion Berberine hydrochloride tablets combined with metformin can effectively reduce the blood glucose,blood lipid,body mass,oxidative stress and inflammatory response in patients with primary type 2 diabetes,and 8-OHdG may be an evaluation index for the prognosis of type 2 diabetes mellitus.