固相萃取-气相色谱质谱联用法检测水中亚硝胺类化合物

Determination of nitrosamines in water by solid phase extraction and gas chromatography-mass spectrometry

建立了水中7种亚硝胺类化合物的固相萃取-气相色谱质谱联用(GC/MSMS)分析方法。对所使用的固相萃取柱、洗脱试剂和升温程序进行了优化,得出了最佳实验条件。实验结果表明,7种目标物线性关系良好,相关系数达到0.999~0.9998,加标回收率达到88.8%~110%,相对标准偏差为1%~6.8%。该方法简便快捷、灵敏度高、稳定性好,适用于水中亚硝胺类物质的检测。

A method for the analysis of seven nitrosamines in water by solid phase extraction and gas chromatography-mass spectrometry(GC/MSMS)was developed.The optimum experimental conditions were obtained by optimizing the SPE column,elution reagent and temperature rise program.The experimental results demonstrate that the linear relationship of the 7 objects is good,the correlation coefficient reaches 0.999~0.9998,the standard recovery rate reaches 88.8%~110%,and the relative standard deviation is 1%~6.8%.The method is easy,rapid,sensitive and stable,and is suitable for the detection of nitrosamines in water.