首发精神分裂症患者血浆游离氨基酸水平及与糖脂代谢指标相关性分析

Analysis of plasma free amino acids in patients with first-episode schizophrenia and their correlations with glucolipid metabolism

目的探索首发精神分裂症患者血浆游离氨基酸水平及与糖脂代谢指标的相关性。方法选取首发精神分裂症患者(病例组)和年龄、性别匹配的健康人(对照组)各40例。基于UPLC-Q-Exactive Orbitrap-MS/MS检测平台对两组血浆样本中的游离氨基酸进行定性定量,用IBM SPSS 22.0统计软件进行数据分析。结果病例组的FBG水平高于对照组(P<0.05)。病例组亮氨酸、异亮氨酸、苏氨酸、天冬酰胺、赖氨酸、组氨酸、色氨酸水平低于对照组(P<0.05),而谷氨酰胺水平高于对照组(P<0.05)。FBG与甘氨酸呈正相关,与谷氨酸呈负相关(P<0.05);TG与脯氨酸、赖氨酸和色氨酸均呈正相关(P<0.05),而与丝氨酸呈负相关(P<0.05);TC则与苏氨酸呈负相关,与赖氨酸呈正相关(P<0.05)。结论首发精神分裂症血浆游离氨基酸水平及糖脂代谢指标存在异常,进一步证实了氨基酸在精神分裂症病理学的作用及其参与糖脂代谢的影响。

Objective To explore the plasma free amino acid levels in patients with first-episode schizophrenia and their correlations with glucolipid metabolism.Methods A total of 40 adults with first-episode schizophrenia(case group)and 40 healthy controls matching the patients in age and sex(control group)were selected.Plasma free amino acid levels of them were analyzed using UPLC-Q-Exactive Orbitrap-MS/MS platform,and data analyses were performed using SPSS 22.0.Results The level of FBG in case group was higher than that in control group(P<0.05).Levels of Leucine,Isoleucine,Threonine,Asparagine,Lysine,Histidine and Tryptophan in case group were lower than those in control group(P<0.05),while the level of Glutamine was higher than that in control group(P<0.05).The level of FBG was positively correlated with glycine level and negatively correlated with glutamic acid level(P<0.05).The level of TG was positively correlated with levels of proline,lysine and tryptophan(P<0.05)and negatively correlated with serine level(P<0.05).The level of TC was negatively correlated with threonine levels and positively correlated with lysine level(P<0.05).Conclusion There exist abnormalities in plasma free amino acid levels and glucolipid metabolism in patients with first-episode schizophrenia,which confirms the role of amino acids in the pathology of schizophrenia and their involvement in glucolipid metabolism.