低频rTMS联合奥拉西坦注射液治疗脑梗死恢复期轻度认知功能障碍患者的临床研究

Clinical Study on Low Frequency rTMS Combined with Oxiracetam Injection in the Treatment of Mild Cognitive Impairment of Patients at the Convalescent Stage of Cerebral Infarction

目的探讨低频重复经颅磁刺激(rTMS)联合奥拉西坦注射液治疗脑梗死恢复期轻度认知功能障碍患者的临床效果。方法选取2016年2月至2018年1月我院收治的脑梗死恢复期轻度认知功能障碍患者83例,随机分为实验组(n=42)和对照组(n=41)。对照组采用奥拉西坦注射液治疗,实验组在对照组基础上采用低频rTMS治疗。观察两组的临床效果及治疗前后认知功能与日常生活能力。结果实验组的治疗总有效率为95.24%,明显高于对照组的73.17%(P<0.05)。治疗前,两组的MoCA、BI评分比较无统计学差异(P>0.05);治疗后,实验组的MoCA、BI评分均明显高于对照组(P<0.05)。结论采用低频rTMS联合奥拉西坦注射液治疗脑梗死恢复期轻度认知功能障碍患者效果显著,可有效改善患者的认知功能,提高其日常生活能力,值得临床推广。

Objective To explore the clinical effect of low frequency repeated transcranial magnetic stimulation(rTMS)combined with oxiracetam injection in the treatment of patients with mild cognitive impairment at the convalescent stage of cerebral infarction.Methods 83 patients with mild cognitive impairment at the convalescent stage of cerebral infarction admitted to our hospital from February 2016 to January 2018 were selected and randomly divided into experimental group(n=42)and control group(n=41).The control group was treated with oxiracetam injection,and the experimental group was treated with low frequency rTMS on the basis of the control group.The clinical effect,and the cognitive function and daily quality of life of the two groups were observed.Results The total effective rate of the experimental group was 95.24%,significantly higher than 73.17%of the control group(P<0.05).Before treatment,no statistical difference was found in the MoCA and BI scores between the two groups(P>0.05).After treatment,the MoCA and BI scores of the experimental group were significantly higher than those of the control group(P<0.05).Conclusions Low frequency rTMS combined with oxiracetam injection has significant effect in the treatment of mild cognitive impairment at the convalescent stage of cerebral infarction,can effectively improve patients'cognitive function and daily quality of life,which is worthy of clinical promotion.