急性冠脉综合征患者心肌甘油三脂含量、微血管功能障碍、心功能变化及其相互关系分析

Analysis on Myocardial Triglyceride Content,Microvascular Dysfunction and Changes of Cardiac Function in Patients with Acute Coronary Syndrome and the Correlation

目的探讨急性冠脉综合征(ACS)患者行介入治疗前后心肌甘油三酯(TG)、微血管功能障碍及心功能变化情况,同时探讨患者生存率的影响因素。方法回顾性分析我院2017年3月至2018年3月收治的65例ACS患者的临床资料,所有患者均行经皮冠状动脉介入治疗,于治疗前后检测患者的心肌指标及心功能情况。随访1年,统计患者的生存率,并采用Pearson线性相关法分析生存率的影响因素。结果与治疗前比较,患者治疗1个月后的心肌TG、冠脉血流速度、FFR及LVEF均改善(P<0.05);患者心肌TG含量与LVEF呈负相关,与TIMI分级和FFR呈正相关(P均<0.05);患者TIMI分级和FFR与LVEF均呈负相关(P<0.05)。与存活患者比较,死亡患者的心肌TG含量、TIMI分级0级和1级比例、FFR<0.75比例均升高(P<0.05)。结论PCI治疗ACS患者具有良好的治疗效果,但治疗后患者的生存率会受多项因素影响,需予以科学的预防及干预。

Objective To analyze the myocardial triglyceride(TG),microvascular dysfunction and changes of cardiac function in patients with acute coronary syndrome(ACS)before and after interventional therapy,and to explore the influencing factors of survival rate.Methods The clinical data of 65 ACS patients admitted to our hospital from March 2017 to March 2018 were retrospectively analyzed.All patients were treated with percutaneous coronary intervention(PCI).The myocardial indicators and cardiac function were detected before and after treatment.Patients were followed up for 1 year,and the survival rate was counted.Pearson linear correlation method was used to analyze the influencing factors of survival rate.Results Compared with those before treatment,the myocardial TG,coronary blood flow velocity,FFR and LVEF 1 month after treatment were improved(P<0.05).The myocardial TG content was negatively correlated with LVEF and positively correlated with TIMI grading and FFR(P<0.05).The TIMI grading and FFR were negatively correlated with LVEF(P<0.05).Compared with the surviving patients,the myocardial TG content,the rate of TIMI grade 0 and grade 1,and the rate of FFR<0.75 increased in the dead patients(P<0.05).Conclusions PCI in the treatment of ACS patients has good treatment effect.The survival rate is often affected by multiple factors after treatment,so scientific prevention and intervention is needed.