早期高渗氯化钠羟乙基淀粉与甘露醇治疗重型颅脑外伤合并失血性休克的疗效比较

Comparison on the Efficacy of Early Hypertonic Sodium Chloride Hydroxyethyl Starch and Mannitol in the Treatment of Severe Craniocerebral Trauma Complicated with Hemorrhagic Shock

目的观察早期高渗氯化钠羟乙基淀粉与甘露醇治疗重型颅脑外伤合并失血性休克的疗效。方法选取2016年2月至2018年3月我院收治的重型颅脑外伤合并失血性休克患者106例,随机将其分为两组各53例。对照组在常规治疗基础上采用甘露醇治疗,观察组则采用早期高渗氯化钠羟乙基淀粉治疗,对比两组患者的临床疗效、凝血功能、炎性因子水平。结果观察组的总有效率高于对照组(P<0.05)。治疗后,观察组的TNF-α、IL-6及CRP水平低于对照组,PT短于对照组,APTT长于对照组(P均<0.05)。结论早期高渗氯化钠羟乙基淀粉与甘露醇治疗重型颅脑外伤合并失血性休克患者,可明显提高临床疗效,改善凝血功能,降低炎性因子水平。

Objective To observe the efficacy of early hypertonic sodium chloride hydroxyethyl starch and mannitol in the treatment of severe craniocerebral trauma complicated with hemorrhagic shock.Methods 106 patients with severe craniocerebral trauma complicated with hemorrhagic shock admitted to our hospital from February 2016 to March 2018 were selected and randomly divided into two groups,with 53 cases in each group.The control group was treated with mannitol on the basis of routine treatment,while the observation group was treated with early hypertonic sodium chloride hydroxyethyl starch.The clinical efficacy,coagulation function and inflammatory factor levels were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group(P<0.05).After treatment,the TNF-α,IL-6 and CRP levels of the observation group were lower than those of the control group,the PT was shorter than that of the control group,and the APTT was longer than that of the control group(all P<0.05).Conclusions Early hypertonic sodium chloride hydroxyethyl starch and mannitol in the treatment of severe craniocerebral trauma complicated with hemorrhagic shock can significantly improve the clinical efficacy and coagulation function,and reduce the inflammatory factor levels.