早孕期糖化血红蛋白检测在妊娠期糖尿病诊断中的应用

Application of glycosylated hemoglobin detection in early pregnancy in diagnosis of gestational diabetes mellitus

目的分析在妊娠期糖尿病诊断中应用早孕期糖化血红蛋白检测的临床价值。方法从2018年7月~2019年1月选取1000例妊娠期糖尿病患者作为研究组,另外选取同期健康妊娠孕妇1000例作为对照组,均行以早孕期糖化血红蛋白检测,并测定空腹血糖、餐后2h血糖,比较检测结果。结果研究组空腹血糖、餐后2h血糖、糖化血红蛋白均高于对照组,且各指标阳性率均高于对照组,差异有统计学意义(P<0.05);两组身高比较差异无统计学意义(P>0.05),研究组体质量、体质量指数、有糖尿病家族史占比均高于对照组,差异有统计学意义(P<0.05)。结论在妊娠期糖尿病诊断中应用早孕期糖化血红蛋白检测的临床价值显著,可以及时将妊娠期糖尿病患者检出,以便于及时进行干预和处理。

Objective To analyze clinical values of glycosylated hemoglobin detection in early pregnancy in diagnosis of gestational diabetes mellitus.Methods 1000 patients with gestational diabetes mellitus from July 2018 to January 2019 were selected as the study group.Another 1,000 healthy pregnant women in the same period were selected as the control group.All patients received glycosylated hemoglobin detection in early pregnancy.Fasting blood glucose and 2h postprandial blood glucose were measured,and results were compared.Results Fasting blood glucose,2h postprandial blood glucose and glycosylated hemoglobin in the study group were all higher than those in the control group and the positive rate of each index was higher than that of the control group.The differences were statistically significant(P<0.05).There was no statistically significant difference in height between the two groups(P>0.05).The proportion of body mass,body mass index and family history of diabetes in the study group was higher than that in the control group,and the difference was statistically significant(P<0.05).Conclusion In the diagnosis of gestational diabetes mellitus,the application of glycosylated hemoglobin detection in early pregnancy has significant clinical value and it can detect patients with gestational diabetes mellitus in time to facilitate timely intervention and management.