喹诺酮类抗生素致心血管不良反应分析

Analysis of Adverse Cardiovascular Reactions Induced by Quinolones

目的分析喹诺酮类抗生素致心血管不良反应。方法对2018年10月至2019年8月四川省雅安市名山区中医医院收治的93例喹诺酮类抗生素致心血管不良反应事进行回顾性分析,分析不同药物导致的心血管不良反应发生情况和发生、恢复时间情况。结果在心血管不良反应情况中,心脏不适发生率为40.86%,心悸和心动过速发生率为23.66%,心尖疼痛发生率为10.75%,左心衰竭发生率为1.08%;心血管不良反应在用药31 min^2 h的发生率为32.26%,6~30 min的发生率为32.26%,2 h后的发生率为9.68%,5 min内的发生率为7.53%;31 min^2 h的恢复率为52.69%,6~30 min的恢复率为29.03%,2 h后的恢复率为18.28%。结论喹诺酮类抗生素在过程中会导致心悸、心脏不适、心动过速、心尖疼痛、和左心衰竭的心血管不良反应,在用药后6 min^2 h内的发生率较高,所以在临床治疗中,需要合理用药和加强药用监测,预防和减少不良反应。

Objective To analyze the adverse cardiovascular reactions induced by quinolones.Methods Totally 93 cases of cardiovascular adverse reactions caused by quinolones in Mingshan Hospital of traditional Chinese medicine,Ya'an City,Sichuan Province from October 2018 to August 2019 were analyzed retrospectively,and the occurrence,recovery time of cardiovascular adverse reactions caused by different drugs were analyzed.Results In cardiovascular adverse reaction,the incidence of cardiac discomfort was 40.86%,the incidence of palpitation and tachycardia was 23.66%,the incidence of apical pain was 10.75%,and the incidence of left heart failure was 1.08%.The incidence of cardiovascular adverse reactions was 32.26%at 31 min^2 h,32.26%at 6 min^30 min,9.68%at 2 h.The incidence within 5 min was 7.53%.The recovery rate of 31 min^2 h was 52.69%,the recovery rate of 6~30 min was 29.03%,and the recovery rate of 2 h was 18.28%.Conclusion Quinolone antibiotics may cause palpitations,cardiac discomfort,tachycardia,apical pain,and left heart failure in the course of treatment,and the incidence of adverse cardiovascular reactions is high within 6 min^2 h after treatment.Therefore,rational drug use and enhanced medical monitoring are needed in clinical treatment to prevent and reduce adverse reactions.