帕罗西汀联合重复经颅磁刺激治疗伴失眠的焦虑症疗效观察

Clinical Observation of Paroxetine Combined with Repetitive Transcranial Magnetic Stimulation in the Treatment of Anxiety Disorder with Insomnia

目的探讨帕罗西汀联合重复经颅磁刺激(rTMS)治疗伴失眠的焦虑症临床疗效及安全性。方法选取2018年1月至12月成都市第四人民医院治疗伴失眠的焦虑症患者150例,根据入院先后顺序分为观察组和对照组,各75例。对照组采用帕罗西汀治疗,观察组联合rTMS,治疗前及治疗后采用汉密尔顿焦虑量表(HAMA)和匹兹堡睡眠质量指数量表(PSQI)评价焦虑及睡眠质量。结果治疗前两组患者HAMA、PSQI评分比较差异无统计学意义(P>0.05);治疗后4周、8周观察组患者HAMA、PSQI评分明显低于对照组,减分率高于对照组,差异有统计学意义(P<0.05)。结论帕罗西汀联合rTMS治疗伴失眠的焦虑症在改善焦虑状态及睡眠质量方面优于单纯应用帕罗西汀治疗。

Objective To investigate the clinical efficacy and safety of paroxetine combined with repetitive transcranial magnetic stimulation(rTMS)in the treatment of anxiety disorder with insomnia.Methods From January to December 2018,150 patients who met the criteria were divided into observation group(n=75)and control group(n=75).The control group was treated with paroxetine and the observation group was treated with rTMS.Before and after treatment,Hamilton anxiety scale(HAMA)and Pittsburgh Sleep quality Index scale(PSQI)were used to evaluate anxiety and sleep quality,respectively.Results There was no significant difference in HAMA and PSQI scores between the two groups before treatment.At 4 and 8 weeks after treatment,the scores of HAMA and PSQI in the observation group were significantly lower than those in the control group,and the score reduction rate in the observation group was significantly higher than that in the control group(P<0.05).Conclusion Paroxetine combined with rTMS is superior to paroxetine alone in improving anxiety state and sleep quality in anxiety disorder with insomnia.