老年人急性早幼粒细胞白血病治疗进展

Progress in the Treatment of Acute Promyelocytic Leukemia in the Elderly

急性早幼粒细胞白血病在现代临床治疗中取得了一定进展,而在对65岁以上老年患者进行治疗时,不仅应当注重于提高患者治疗效果,还应当注重降低治疗期间的不良反应,其中主要包括诱导治疗方案的改进和巩固以及治疗策略的优化。目前临床上将全反式维酸钾联合化疗作为基础方案,应用于急性早幼粒细胞白血病老年患者的治疗中,获得了良好预后,提高了老年患者的病症完全缓解率。同时这种治疗方案可根据患者危险度不同对其进行分层治疗,这样能够在提高巩固效果的同时,降低血液学复发风险,使这种病症的治疗成为个体化治疗的典范。

Acute promyelocytic leukemia has made some progress in modern clinical treatment.For elderly patients over 65 years old,we should focus on not only improving the treatment effect,but also reducing adverse reactions during treatment.It mainly includes the improvement and consolidation of induction treatment programs and the optimization of treatment strategies.At present,all-trans potassium phosphate combined with chemotherapy is used as a basic program in the treatment of elderly patients with acute promyelocytic leukemia,and a good prognosis is obtained,which improves the complete remission rate of elderly patients.At the same time,this treatment can be treated according to the patient's risk,which can improve the consolidation effect,reduce the risk of hematological recurrence,and make the treatment of this disease become a model of individualized treatment.