华中某国企职工高尿酸血症患病率及其与相关生化指标关系的研究

Relationship between the prevalence of hyperuricemia and biochemical indicators among employees in an enterprise in central China

目的了解华中某国企职工高尿酸血症(HUA)的患病率及其与相关生化指标之间的关系。方法收集2018年湖北省电力职工医院职工健康体检数据,检测指标包括尿酸(UA)、肌酐(CRE)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、载脂蛋白AⅠ(Apo-AⅠ)、载脂蛋白B (Apo-B)、空腹血糖(FBG)、丙氨酸氨基转移酶(ALT)等。采用SPSS 19.0软件分析HUA发生的影响因素,单因素分析采用t检验和χ^2检验,多因素采用logistic回归分析。结果共有1 948名职工的资料纳入分析,其中男性1 094人(56.16%)、女性854人(43.84%),平均血尿酸水平为(295.61±89.88)μmol/L,HUA患病率为11.34%。男性HUA患病率(16.27%)高于女性(5.04%),差异有统计学意义(χ^2=48.655,P<0.001)。男、女职工HUA患病率均随着年龄增长逐渐上升(P<0.001),且在30~39岁、40~49岁、50~59岁年龄段,男性均明显高于女性(P<0.05)。单因素分析结果显示,高尿酸组与尿酸正常组在性别及ALT、FBG、CRE、TC、TG、HDL、 LDL、Apo-B等水平上的差异均有统计学意义(P<0.05);多因素logistic回归结果显示,Apo-B、TG、CRE和ALT高水平为HUA发生的危险因素,OR值(95%CI)分别为19.617 (3.684-60.897)、1.322 (1.088-1.464)、1.057 (1.042-1.071)和1.011 (1.003-1.017)。结论湖北电力职工高尿酸血症患病率较高,其发病与高TG、ApoB、CRE、ALT相关,提示HUA与肝肾功能异常及多种心血管疾病存在协同效应。

Objective To explore the relationship between hyperuricemia(HUA) and biochemical indicators among employees in a state owned enterprise in central China.Methods The data of health examination of power workers at Hubei Electric Power Staff Hospital in 2018 were collected.The detection indicators included uric acid(UA),creatinine(CRE),total cholesterol(TC),triglycerides(TG),high density lipoprotein(HDL),low density lipoprotein(LDL),apolipoprotein A I(Apo-A I),apolipoprotein B(Apo-B),fasting blood glucose(FBG),alanine aminotransferase(ALT),etc.SPSS 19.0 software was used to analyze the influencing factors of HUA.The univariate analysis was performed by t test and chi-square test.Multivariate analysis was performed by logistic regression model.Results A total of 1 948 employees were included in the analysis,including 1 094 males(56.16%) and 854 females(43.84%).The average blood uric acid level was(295.61±89.88) μmol/L,and the prevalence of HU A was 11.34%.The prevalence of HUA in men(16.27%) was higher than in women(5.04%),and the difference was statistically significant(χ^2=48.655,P<0.001).The prevalence of HUA for both male and female employees increased gradually with age(P<0.001);moreover,in the age group of 30-39 years old,40-49 years old,and 50-59 years old,men were significantly higher than women(P<0.05).The univariate analysis showed that the differences in gender,level of ALT,FBG,CRE,TC,TG,HDL,LDL,and Apo-B were statistically significant between HUA group and normal uric acid group(P<0.05).The multivariate logistic regression analysis showed that higher levels of Apo-B,TG,CRE and ALT were the risk factors for HUA,with OR value(95% CI)of 19.617(3.684-60.897),1.322(1.088-1.464),1.057(1.042-1.071),and 1.011(1.003-1.017),respectiverly.Conclusion The prevalence of hyperuricemia was high among Hubei power workers.High TG,high Apo-B,high CRE,and high ALT were the risk factors of hyperuricemia,implying that there is a synergistic effect among HUA,abnormal kidney function,and cardiovascular diseases.