经典名方中半夏剂量的考订与建议

Textual Research and Suggestions on Dosage of Pinelliae Rhizoma in Famous Classical Formulas

半夏为有毒中药,古今使用剂量相差甚大,在经典名方研发时难以确定。文献考证后发现,经典名方中半夏的剂量经历了由大变小的过程,本着"遵从经典,符合药典"为原则,并结合现代实际应用情况,拟确定《古代经典名方目录(第一批)》所载17首含半夏的方剂中合理的半夏剂量。通过对这17首经典名方的原书记载、历代演变、现在临床运用及其剂型、服用方法等进行考量,建议半夏厚朴汤与麦门冬汤中半夏剂量15.0 g,温胆汤和桑白皮汤中半夏剂量6.0 g,旋覆代赭汤、竹叶石膏汤、半夏泻心汤、甘草泻心汤、黄连汤、瓜蒌薤白半夏汤、厚朴麻黄汤、金水六君煎中半夏剂量均为7.5 g,竹茹汤中半夏剂量6.7 g,升阳益胃汤中半夏剂量4.5 g,养胃汤中半夏剂量5.0 g,半夏白术天麻汤与藿朴夏苓汤中半夏剂量均为5.6 g。

Pinelliae Rhizoma is a toxic traditional Chinese medicine,and its dose differs greatly between at ancient and modern times,so that it is difficult for researchers to determine its dosage during research and development of famous classical formulas.According to the literature research,it is found that the dose of Pinelliae Rhizoma in famous classical formulas has undergone a process from large to small.Based on the principle of"following the classic and conforming to pharmacopoeia",and in combination with the modern actual situation,the reasonable dose of Pinelliae Rhizoma in the 17 formulas from the Catalogue of Ancient Famous Classical Formulas(The First Batch)is determined.According to the records of the original book,the evolution of past dynasties and the consideration of the current clinical application,dosage regimen and administration methods of the 17 famous classical formulas and so on,the authors suggested that the dosages of Pinelliae Rhizoma in Banxia Houpotang and Maimendong Tang are 15.0 g,its dosages in Wendantang and Sangbaipi Tang are 6.0 g,dosages of Pinelliae Rhizoma in Xuanfu Daizhe Tang,Zhuye Shigaotang,Banxia Xiexintang,Gancao Xiexintang,Huangliantang,Gualou Xiebai Banxiatang,Houpo Mahuangtang and Jinshui Liujunjian are 7.5 g,the dosages of Pinelliae Rhizoma in Zhurutang,Shengyang Yiweitang and Yangweitang are 6.7,4.5,5.0 g,respectively,dosages of Pinelliae Rhizoma in Banxia Baizhu Tianma Tang and Huopo Xialing Tang are 5.6 g.