飞秒激光小切口角膜基质透镜取出术人体角膜基质透镜再利用的研究新进展

New progress in the reuse of human corneal stromal lenticules from SMILE

随着飞秒激光小切口角膜基质透镜取出术(SMILE)在临床的广泛开展,术中大量的一片式角膜基质透镜被完整地取出,从而引发学者们开始对人体角膜基质透镜的再利用进行了研究。在基础方面,主要从细胞生物学、免疫学及生物力学角度,将透镜用于培养角膜成纤维细胞、构建生物角膜支架、描述角膜的生物力学行为等;在临床方面,将透镜植入自体或同种异体的角膜,以矫治远视和老视、修补角膜溃疡穿孔、治疗角膜缺陷性疾病等,收到了良好的效果。

With the extensive development of small incision lenticule extraction(SMILE),a large number of human corneal stromal lenticules were extracted integrally during the operation,which led some experts to study the reuse of the lenticules.In experimental research,the lenticules were used to culture fibroblasts,construct corneal scaffolds and describe the biomechanical behaviors of cornea by cytobiology,immunology and biomechanics.In clinical study,the lenticules had been successfully reimplanted into autologous or allogenic cornea of human subjects for correcting hyperopia and presbyopic,patching corneal perforation and treating defective keratopathy and so on.