摘要
To the Editor:Germ-cell tumors(GCTs)of the central nervous system(CNS),the morphologic,immunophenotypic,and(in some respects)genetic homologs of gonadal and other extraneuraxial germ-cell neoplasms,principally affect children and adolescents.[1]The diagnosis of GCT of the CNS is not difficult,and the major GCT types are germinoma,teratoma,yolk sac tumor(YST),embryonal carcinoma,and choriocarcinoma.Neoplasms harboringmultiple types are calledmixed GCT(MGCT).Peak incidence of GCT of the CNS occurs in patients aged 10 to 14 years,and a clear majority of cases of all histologic types involve males.GCT of the CNS seems to be more prevalent in eastern Asia than in Europe and the United States.[1-5]In Japan,70%of patients withGCT of CNS aged 10 to 24 years and 73%were males,[6]but there were limited Chinese patients’large-scale data,only two studies reportedmore than 100 cases.[7,8]Were the types and clinical characteristics of GCTs in the CNS in Chinese patients consistent with Japan’s?We reviewed all cases of GCTs in the CNS diagnosed by pathology in Peking Union Medical College Hospital from year 1999 to 2019.We retrospectively collected and analyzed all cases underwent optical microscopy and immunohistochemical staining examinations,aiming to summarize and analyze the clinicopathologic features of them.
