超声波促进新型席夫碱类化合物的水相合成

Ultrasound-assisted Synthesis of Novel Schiff Bases in Aqueous Condition

在超声波促进下以聚乙二醇(PEG 6000)为相转移催化剂,在水相中合成了8个席夫碱类化合物。采用1HNMR、13CNMR、IR、MS(ESI)和X-射线衍射对其结构进行了表征,结果与目标化合物一致。采用相转移催化剂水相超声波合成,与传统的加热反应或有机溶剂相超声波合成比较,水相超声波合成不但可以避免使用酸碱催化剂和乙醇等挥发性溶剂,而且使得反应时间从数小时缩短至0.5 h左右,产率高达76%~92%。经查证,其中6个席夫碱类化合物是未见文献报道的新化合物。

Eight Schiff bases were synthesized by aqueous phase with polyethylene glycol(PEG 6000) as phase transfer catalyst under ultrasonic radiation.The structures were confirmed by 1HNMR,13CNMR,IR,MS(ESI) and X-ray and were consistent with the target compounds.Compared with the traditional heating reaction or the organic solvent phase ultrasonic synthesis,the aqueous phase ultrasonic synthesis with phase transfer catalyst could not only avoid the volatile solvents such as acid-base catalyst and ethanol,but also shorten the reaction time from several hours to about 0.5 h,and the yield was as high as 76% to 92%.It was verified that six Schiff bases were new compounds which were not reported in the literature.