血清膜联蛋白A2在冠心病患者血清中明显升高

Serum annexin A2 level is significantly elevated in patients with coronary heart disease

目的探究血清膜联蛋白A2(AnnexinⅡ)与冠状动脉粥样硬化性心脏病(CAD)及其严重程度的关系。方法收集2017年8月~2019年8月在南方医科大学南方医院心血管内科住院患者200例,根据根据冠脉造影结果分成冠心病组(CAD,n=150)和非冠心病组(NON-CAD,n=50);CAD患者根据临床稳定性分为稳定性心绞痛组(SAP组)和急性冠脉综合征组(ACS组),检测患者血清AnnexinⅡ、MPO、PON1水平,并分析其与罹患冠心病、冠心病严重程度,冠脉病变狭窄程度的相关性。结果 CAD组患者AnnexinⅡ、MPO水平明显高于NON-CAD患者(P<0.05);且在冠心病患者中,ACS组较SAP组具有更高水平的AnnexinⅡ(P<0.05)和更低水平的PON-1(P<0.05)。但AnnexinⅡ与冠脉病变支数、Gensini积分、以及冠心病患者中是否合并糖尿病无明显相关性。结论冠心病患者血清中AnnexinⅡ明显升高,并且在ACS患者中更加明显,可作为临床不稳定事件的预测指标。

Objective To analyze the correlation of annexin A2 with coronary atherosclerotic heart disease(CAD) and the severity of CAD. Methods We collected data from a total of 200 inpatients admitted in our department between August, 2017 and August, 2019. According to the results of coronary angiography, the patients were divided into CAD group(n=150) and non-CAD(n=50), and the CAD patients was further divided, according to their clinical stability, into stable angina(SAP) group and acute coronary syndrome(ACS) group. Serum levels of annexin A2, MPO and PON1 were detected in all these patients,and their correlations with CAD, disease severity, and degree of coronary artery stenosis were analyzed. Results The levels of annexin A2 and MPO were significantly higher in CAD patients than in non-CAD patients(P<0.05). Among the CAD patients,those with ACS had significantly higher levels of annexin A2(P<0.05) and lower levels of PON-1(P<0.05) than those with SAP,but annexin A2 level was not significantly correlated with coronary lesion count, Gensini score, or the co-morbidity of diabetes. Conclusion Annexin A2 is significantly elevated in patients with CAD, especially in those with ACS, and can be used as a predictor of clinical instability.