摘要
以二芳基乙酮(4a^4f)和取代丙酮(5a^5c)为原料,KHCO3为碱,100℃空气条件下,在DMSO中经二芳基乙酮氧化、羟醛缩合一锅法合成了12个羟基环戊烯酮化合物(6a^6l),其中6d, 6h和6i为新化合物,其结构经1H NMR,13C NMR和HR-MS(ESI)表征。
Hydroxycyclopentenone compounds(6 a^6 l) were synthesized via one-pot method at 100 ℃, using diaryl acetophenone compounds(4 a^4 f) and substituted acetone compounds(5 a^5 c) as starting materials, KHCO3 as base, DMSO as solvent, consisting of diphenylacetone oxidation and aldol condensation. Among them, 6 d, 6 h and 6 i were novel compounds. The structures were characterized by 1H NMR, 13C NMR and HR-MS(ESI).
作者
陈卫达
马永敏
CHEN Wei-da;MA Yong-min(Collegel of Pharmaceutical Science,Zhejiang Chinese Medical University,Hangzhou 311400,China;School of Advanced Study,Taizhou University,Taizhou 318000,China)
出处
《合成化学》
CAS
北大核心
2020年第3期202-208,共7页
Chinese Journal of Synthetic Chemistry
基金
浙江省自然科学基金资助项目(YH17H300005)。
关键词
一锅法
羟基环戊烯酮
二芳基乙酮
取代丙酮
羟醛缩合
合成
one-pot
hydroxycyclopentenone
diaryl acetophenone
substituted acetone
aldol condensation
synthesis
