吉西他滨联合放疗治疗老年中晚期宫颈癌患者的临床研究

Clinical study of Gemcitabine combined with radiotherapy for elderly patients with advanced cervical cancer

目的探讨吉西他滨联合放疗治疗老年中晚期宫颈癌患者的临床效果。方法选取2016年12月至2018年8月本院收治老年中晚期宫颈癌患者84例,按照随机、对照原则将其分为单纯放疗组和联合放疗组,其中联合放疗组在单纯放疗的基础上联合吉西他滨,对两组患者近期疗效、远期疗效和不良反应发生情况进行评估分析。结果两组患者经过治疗其肿瘤均得到有效控制,其中单纯放疗组患者总治疗有效率为67.6%,低于联合放疗组(87.2%)(χ2=4.756,P=0.029);联合放疗组患者生存率(89.4%和59.5%,χ2=10.204,P=0.001)、无局部复发率(83.0%和54.1%,χ2=8.286,P=0.004)、无远处转移生存率(83.0%和56.8%,χ2=6.975,P=0.008)均高于单纯放疗组;联合放疗组患者白细胞减少发生率高于单纯放疗组(38.3%和13.5%,χ2=8.396,P=0.011)。结论采用放疗联合吉西他滨治疗老年中晚期宫颈癌,可有效增强对患者癌变组织的控制效果,提高患者远期生存率,降低肿瘤局部复发风险。

Objective To explore the clinical efficacy of Gemcitabine in combination with radiotherapy for elderly patients with cervical cancer.Methods From December 2016 to August 2018,84 elderly patients with advanced cervical cancer receiving treatment in our hospital were enrolled.As a randomized controlled study,patients were divided into the radiotherapy-alone group and the combined therapy group.Patients in the combined therapy group was given radiotherapy and Gemcitabine.The short-and long-term efficacy,and the rate of adverse reactions were evaluated for the two groups.Results Tumors in both groups were effectively controlled after treatment.The overall rate of effectiveness in the radiotherapy-alone group was significantly lower than that in the combined therapy group(67.6%vs.87.2%,χ2=4.756,P=0.029).The combined therapy group was associated with a significantly higher survival rate(89.4%vs.59.5%,χ2=10.204,P=0.001),a local recurrence-free rate(83.0%vs.54.1%,χ2=8.286,P=0.004),and a distant metastasis-free survival rate(83.0%vs.56.8%,χ2=6.975,P=0.008),compared with the radiotherapy-alone group.Additionally,the incidence of leukopenia was higher in the combined therapy group than in the radiotherapy-alone group(38.3%vs.13.5%,χ2=8.396,P=0.011).Conclusion The combination of radiotherapy with Gemcitabine for the treatment of advanced cervical cancer in elderly patients can effectively enhance control on cancerous tissues,improve the long-term survival rate,and reduce the risk of local recurrence.