病原体感染促阿尔茨海默病发病学说的研究进展

Advances in research on the pathogenesis of pathogen infection promoting Alzheimer′s disease

目前有关阿尔茨海默病(AD)发病机制研究不断更新,经典的β淀粉样蛋白瀑布学说、tau蛋白学说依然是AD发病机制的主流学说。包括肠道菌群在内的病原体感染促进AD发病学说逐步引起重视,充分补充了现有学说。我们通过查阅近10年来关于病原体感染促AD发病的文献,总结病原体促进AD发病的可能机制,并提出早期干预措施。

The research on the pathogenesis of Alzheimer′s disease(AD)is constantly updated nowadays.The amyloid cascade hypothesis and the theory of tau protein are the mainstream theory of the pathogenesis of AD.The theory that pathogen infection,including intestinal flora,increases the incidence of AD has gradually gained attention and fully supplements existing doctrines.By reviewing the literature on the pathogenesis of AD in the past 10 years,the possible mechanisms by which pathogens increase the incidence of AD were summarized and early interventions were proposed.