高尿酸、高同型半胱氨酸血症对脑梗死患者基底节钙化发生的影响

Effect of Hyperuricemia and Hyperhomocysteinemia on Basal Ganglia Calcification in Patients with Cerebral Infarction

目的:分析高尿酸、高同型半胱氨酸血症(HHcy)对脑梗死患者基底节钙化发生的影响。方法:回顾性分析本院2016年1月-2017年12月65例脑梗死患者的临床资料,根据患者是否发生基底节钙化,分为A组(无基底节钙化)和B组(发生基底节钙化)。比较两组临床基本资料、血清碱性磷酸酶(ALP)、血钙、尿酸和同型半胱氨酸(Hcy)水平的差异。结果:65例患者中,发生基底节钙化29例,发生率为44.62%;两组性别、年龄、糖尿病、高血压发生率比较,差异均无统计学意义(P>0.05);B组血清ALP水平明显低于A组(P<0.05);两组血钙水平比较,差异无统计学意义(P>0.05);B组血清尿酸和Hcy水平均明显高于A组,差异均有统计学意义(P<0.05)。结论:发生基底节钙化的脑梗死患者可能伴有高尿酸、HHcy的临床特征,且ALP可能参与基底节钙化的发生。

Objective:To analyze the effect of hyperuricemia and hyperhomocysteinemia(HHcy)on basal ganglia calcification in patients with cerebral infarction.Method:The clinical data of 65 patients with cerebral infarction in our hospital from January 2016 to December 2017 were retrospectively analyzed.According to whether the patients had basal ganglia calcification,they were divided into group A(no basal ganglia calcification)and group B(basal ganglia calcification).The basic clinical data,serum alkaline phosphatase(ALP),serum calcium,uric acid and homocysteine(Hcy)levels were compared between the two groups.Result:Among the 65 patients,29 cases had basal ganglia calcification,the incidence was 44.62%.There were no significant differences in gender,age,incidence of diabetes and hypertension between the two groups(P>0.05).The level of ALP in group B was significantly lower than that in group A(P<0.05).The blood calcium levels of the two groups were compared,the difference was not statistically significant(P>0.05).The levels of serum uric acid and Hcy in group B were significantly higher than those in group A,the differences were statistically significant(P<0.05).Conclusion:Cerebral infarction patients with basal ganglia calcification may have clinical features of hyperuricemia and HHcy,and ALP may be involved in the occurrence of basal ganglia calcification.