替格瑞洛对急性ST段抬高型心肌梗死患者PCI术后心功能指标及预后的影响

Effect of Ticagrelol on Cardiac Function Indexes and Prognosis in Patients with Acute ST Segment Elevation Myocardial Infarction after PCI

目的:探讨替格瑞洛对急性ST段抬高型心肌梗死(ST elevation myocardial infarction,STEMI)患者经皮冠状动脉介入术(percutaneous coronary intervention,PCI)后心功能指标及预后的影响。方法:选择2015年9月-2018年9月在本院行PCI治疗的90例STEMI患者,按随机数字表法分为A组和B组,各45例。A组给予替格瑞洛联合阿司匹林治疗,B组给予氯吡格雷联合阿司匹林治疗。比较两组术后心功能指标、血清超敏C反应蛋白(hs-CRP)、磷酸肌酸激酶同工酶(CK-MB)、主要不良心血管事件(MACE)、出血事件和不良反应发生情况。结果:A组左心室射血分数(LVEF)高于B组,左心室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)、血清hs-CRP、CK-MB水平、MACE发生率均低于B组,差异均有统计学意义(P<0.05);A组出血事件发生率与B组相比,差异无统计学意义(P>0.05)。结论:替格瑞洛可有效改善STEMI患者PCI后心功能,减轻心肌损伤,降低炎症反应程度,减少MACE发生,改善患者预后。

Objective:To investigate the effect of Ticagrelol on cardiac function indexes and prognosis in patients with acute ST elevation myocardial infarction(STEMI)after percutaneous coronary intervention(PCI).Method:A toatal of 90 STEMI patients who underwent PCI in our hospital from September 2015 to September 2018 were selected,they were divided into group A and group B according to the random number table method,45 cases in each group.Group A was treated with Ticagrelol combined with Aspirin,group B was treated with Clopidogrel and Aspirin.The cardiac function indexes,serum hypersensitive C-reactive protein(hs-CRP),creatine kinase isoenzymes(CK-MB),major adverse cardiovascular events(MACE),incidence of bleeding events and adverse reactions of two groups were compared.Result:The left ventricular ejection fraction(LVEF)of group A was higher than that of group B,left ventricular end diastolic diameter(LVEDD),left ventricular end systolic diameter(LVESD),serum hs-CRP,CK-MB and the incidence of MACE were lower than those of group B(P<0.05).There was no significant difference in the incidence of bleeding events between group A and group B,the differences were statistically significant(P>0.05).Conclusion:Ticagrelol can effectively improve the cardiac function,reduce myocardial injury,reduce the degree of inflammation,reduce the incidence of mace and improve the prognosis of patients with STEMI after PCI.