摘要
目的:探讨替格瑞洛对急性ST段抬高型心肌梗死(ST elevation myocardial infarction,STEMI)患者经皮冠状动脉介入术(percutaneous coronary intervention,PCI)后心功能指标及预后的影响。方法:选择2015年9月-2018年9月在本院行PCI治疗的90例STEMI患者,按随机数字表法分为A组和B组,各45例。A组给予替格瑞洛联合阿司匹林治疗,B组给予氯吡格雷联合阿司匹林治疗。比较两组术后心功能指标、血清超敏C反应蛋白(hs-CRP)、磷酸肌酸激酶同工酶(CK-MB)、主要不良心血管事件(MACE)、出血事件和不良反应发生情况。结果:A组左心室射血分数(LVEF)高于B组,左心室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)、血清hs-CRP、CK-MB水平、MACE发生率均低于B组,差异均有统计学意义(P<0.05);A组出血事件发生率与B组相比,差异无统计学意义(P>0.05)。结论:替格瑞洛可有效改善STEMI患者PCI后心功能,减轻心肌损伤,降低炎症反应程度,减少MACE发生,改善患者预后。
Objective:To investigate the effect of Ticagrelol on cardiac function indexes and prognosis in patients with acute ST elevation myocardial infarction(STEMI)after percutaneous coronary intervention(PCI).Method:A toatal of 90 STEMI patients who underwent PCI in our hospital from September 2015 to September 2018 were selected,they were divided into group A and group B according to the random number table method,45 cases in each group.Group A was treated with Ticagrelol combined with Aspirin,group B was treated with Clopidogrel and Aspirin.The cardiac function indexes,serum hypersensitive C-reactive protein(hs-CRP),creatine kinase isoenzymes(CK-MB),major adverse cardiovascular events(MACE),incidence of bleeding events and adverse reactions of two groups were compared.Result:The left ventricular ejection fraction(LVEF)of group A was higher than that of group B,left ventricular end diastolic diameter(LVEDD),left ventricular end systolic diameter(LVESD),serum hs-CRP,CK-MB and the incidence of MACE were lower than those of group B(P<0.05).There was no significant difference in the incidence of bleeding events between group A and group B,the differences were statistically significant(P>0.05).Conclusion:Ticagrelol can effectively improve the cardiac function,reduce myocardial injury,reduce the degree of inflammation,reduce the incidence of mace and improve the prognosis of patients with STEMI after PCI.
作者
丁琦
DING Qi(Gaizhou City Integrated Hospital of Traditional Chinese and Western Medicine,Gaizhou 115200,China)
出处
《中国医学创新》
CAS
2020年第8期23-26,共4页
Medical Innovation of China
关键词
急性ST段抬高型心肌梗死
替格瑞洛
经皮冠状动脉介入术
心功能指标
Acute ST segment elevation myocardial infarction
Ticagrelol
Percutaneous coronary intervention
Cardiac function indexes