琥珀酸美托洛尔缓释片治疗心梗后室性心律失常的临床效果

The Clinical Effect of Metoprolol Succinate Sustained-release Tablet in the Treatment of Ventricular Arrhythmia after Myocardial Infarction

目的:研究应用琥珀酸美托洛尔缓释片治疗心梗后室性心律失常的临床效果。方法:选取2018年8月-2019年8月在广州市老人院与广东省人民医院收治的心梗后室性心律失常患者120例作为研究对象,按照治疗方法不同分为观察组(61例)和对照组(59例)。对照组采用盐酸氨基葡萄糖胶囊治疗,观察组采用琥珀酸美托洛尔缓释片治疗。对比两组治疗前后的QT离散度、心率、血压状况以及临床整体治疗效果。结果:治疗后,观察组的QTd、QTcd、心率分别为(46.9±19.7)ms、(47.9±18.7)ms、(74.5±12.1)次/min,均优于对照组的(72.3±15.2)ms、(71.6±16.5)ms、(100.2±11.6)次/min,差异均有统计学意义(P<0.05)。治疗后,观察组的收缩压、舒张压分别为(103.5±12.1)、(75.2±12.3)mm Hg,均低于对照组的(128.3±12.7)、(89.2±11.9)mm Hg,差异有统计学意义(P<0.05)。治疗后,观察组的总有效率为98.36%,高于对照组的79.66%,差异有统计学意义(P<0.05)。结论:采用琥珀酸美托洛尔缓释片治疗心梗后室性心律失常患者,QT离散度明显下降,患者的血压与心率也有更为显著的改善,临床整体治疗效果较好,应该广泛推荐应用。

Objective:To study the clinical efficacy of Metoprolol Succinate Sustained-release Tablets in the treatment of ventricular arrhythmia after myocardial infarction.Method:From August 2018 to August 2019,a total of 120 patients with ventricular arrhythmia after myocardial infarction were selected as the study subjects in Home for the Aged Guangzhou Center and Guangdong People’s Hospital from August 2018 to August 2019.According to different treatment methods,the patients were divided into observation group(61 cases)and control group(59 cases).The control group was treated with Glucosamine Hydrochloride Capsule,while the observation group was treated with Metoprolol Succinate Sustained-release Tablets.The QT dispersion,heart rate,blood pressure and overall clinical efficacy of the two groups were compared before and after treatment.Result:After treatment,QTd,QTcd and heart rate in the observation group were(46.9±19.7)ms,(47.9±18.7)ms and(74.5±12.1)times/min,respectively,which were all better than(72.3±15.2)ms,(71.6±16.5)ms and(100.2±11.6)times/min in the control group,with statistically significant differences(P<0.05).After treatment,the systolic and diastolic blood pressures of the observation group were(103.5±12.1)and(75.2±12.3)mm Hg,respectively,which were lower than(128.3±12.7)and(89.2±11.9)mm Hg of the control group,with statistically significant differences(P<0.05).After treatment,the total effective rate of the observation group was 98.36%,higher than 79.66%of the control group,with statistically significant difference(P<0.05).Conclusion:In the treatment of patients with ventricular arrhythmia after myocardial infarction with Metoprolol Succinate Sustained-release Tablets,QT dispersion decreased significantly,and the blood pressure and heart rate of the patients also improved more significantly,the overall clinical treatment effect is better,and the application should be widely recommended.