乙肝肝硬化患者心电图特征与血清PCT及预后的关系分析

Analysis of the Relationship between Electrocardiogram Characteristics and Serum PCT and Prognosis in Patients with Hepatitis B Cirrhosis

目的:探究乙肝肝硬化患者心电图特征与血清降钙素原(PCT)及预后的关系分析。方法:选取2018年1月-2019年7月本院收治的乙肝肝硬化患者(肝硬化组)128例、乙型肝炎患者(肝炎组)70例以及同期体检正常者(正常组)75例,所有受试者均进行心电图检测。分析乙肝肝硬化患者心电图参数异常与血清PCT的关系。结果:肝炎组及正常组心电图异常占比均低于肝硬化组,差异均有统计学意义(P<0.05);肝硬化组和肝炎组ST-T改变占比显著高于正常组,差异均有统计学意义(P<0.05);肝硬化组左心室肥大、QTc间期延长占比均显著高于肝炎组和正常组,差异均有统计学意义(P<0.05)。A组患者血清PCT水平显著高于B组,差异有统计学意义(P<0.001);C组患者血清PCT水平显著高于D组,差异有统计学意义(P<0.001)。Pearson相关性分析显示,QTc间期延长、左心室肥大均与血清PCT呈正相关(P<0.05)。结论:QTc期间延长和左心室肥大均与乙肝肝硬化患者血清PCT及预后密切相关,可能是乙肝肝硬化预后的独立预测因素。

Objective:To investigate the relationship between electrocardiographic characteristics and serum procalcitonin (PCT) and prognosis in patients with hepatitis B cirrhosis.Method:A total of 128 cases of hepatitis B cirrhosis (cirrhosis group),70 cases of hepatitis B (hepatitis group) and 75 cases of normal physical examination (normal group) admitted to our hospital from January 2018 to July 2019 were selected.All subjects underwent electrocardiogram testing.The relationship between abnormal electrocardiographic parameters and serum PCT in patients with hepatitis B cirrhosis were analyzed.Result:The proportion of abnormal electrocardiographic in hepatitis group and normal group were lower than those in cirrhosis group,the differences were statistically significant (P<0.05).The proportion of ST-T change in cirrhosis group and hepatitis group were significantly higher than those in normal group,the differences were statistically significant (P<0.05).The proportion of left ventricular hypertrophy and QTc interphase prolonging in cirrhosis group were significantly higher than those in hepatitis group and normal group,the differences were statistically significant (P<0.05).The serum PCT level in group A was significantly higher than that in group B,the difference was statistically significant (P<0.001).The serum PCT level in group C was significantly higher than that in group D,the difference was statistically significant (P<0.001).According to Pearson correlation analysis,prolonged QTc interphase and left ventricular hypertrophy were positively correlated with serum PCT (P<0.05).Conclusion:The prolongation of QTc and left ventricular hypertrophy are closely related to serum PCT and prognosis in patients with hepatitis B cirrhosis,which may be an independent predictor of prognosis of hepatitis B cirrhosis.