血管性痴呆和阿尔茨海默病血清炎症因子、临床生化指标的变化

Changes of Serum Inflammatory Factors and Clinical Biochemical Indicators in Vascular Dementia and Alzheimer’s Disease

目的:分析检测血管性痴呆(VD)和阿尔茨海默病(AD)血清炎症因子和临床生化指标的变化,为临床提供检测依据。方法:选取AD患者50例(AD组)和VD患者50例(VD组)以及收集同期健康老年人体检合格者50例作为正常对照组进行研究,检测三组血清炎症因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、人白细胞介素-1α(IL-1α)和人白细胞介素-1β(IL-1β)]和生化指标[载脂蛋白E(apoE)、载脂蛋白B(apoB)、载脂蛋白A(apoA)、同型半胱氨酸(Hcy)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)和甘油三酯(TG)],比较三组各指标的变化。结果:AD组和VD组TNF-α、IL-6及IL-1β均明显高于正常对照组,差异均有统计学意义(P<0.05),但AD组和VD组相比,差异均无统计学意义(P>0.05);三组IL-1α比较,差异均无统计学意义(P>0.05)。与正常对照组相比,AD组和VD组中LDL-C、TG和Hcy均明显增高,差异有统计学意义(P<0.05),HDL-C和apoA均明显降低,差异均有统计学意义(P<0.05);AD组和VD组TG相比,差异有统计学意义(P<0.05),但两组其他指标比较,差异均无统计学意义(P>0.05);三组TC、apoB和apoE比较,差异均无统计学意义(P>0.05)。结论:血清炎症因子和生化指标为VD和AD在临床上的诊断提供了一定的检测依据。

Objective:To analyze the changes of serum inflammatory factors and clinical biochemical markers in patients with vascular dementia(VD)and Alzheimer’s disease(AD),and providing evidence for clinical examination.Method:A total of 50 patients with AD(AD group)and 50 patients with VD(VD group),and 50 healthy old people who passed the physical examination in the same period were collected as the normal control group.The serum inflammatory factor[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),human interleukin-1α(IL-1α)and human interleukin-1β(IL-1β)]and biochemical markers[Lipoprotein E(apoE),apolipoprotein B(apoB),apolipoprotein A(apoA),homocysteine(Hcy),total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C)and triglyceride(TG)]of three groups were detected,the changes in various indicators of three groups were compared.Result:The TNF-α,IL-6 and IL-1βin AD group and VD group were significantly higher than those in the normal control group,and the differences were statistically significant(P<0.05),but there were no significant differences between AD group and VD group(P>0.05).There were no significant differences in IL-1αamong three groups(P>0.05).Compared with the normal control group,LDL-C,TG and Hcy in AD group and VD group were significantly increased,the HDL-C and apoA were significantly lower,and the differences were statistically significant(P<0.05).TG of AD group and VD group compared,the difference was statistically significant(P<0.05),and the differences of other indexes in two groups were not statistically significant(P>0.05).There were no significant differences in TC,apoB and apoE among three groups(P>0.05).Conclusion:Serum inflammatory factors and biochemical indicators provide a basis for the clinical diagnosis of VD and AD.