新生儿听力筛查结果及高胆红素血症对新生儿听力的影响

Neonatal Hearing Screening Results and the Effect of Hyperbilirubinemia on Neonatal Hearing

目的:分析新生儿听力筛查结果并探讨高胆红素血症对新生儿听力的影响。方法:选取2016年6月-2019年6月本院收治的100例高胆红素血症新生儿,根据总胆红素值(TBiL)分为甲组(220.6μmol/L≤TBiL≤340μmol/L,n=65)与乙组(TBiL>340.0μmol/L,n=35)。另选取同期本院足月正常新生儿100例作为对照组。比较甲组与乙组TBiL、pH值、血清白蛋白(ALB)及平均黄疸消退时间;比较三组听力障碍严重程度及筛查通过率。结果:甲组TBiL水平与平均黄疸消退时间均低于乙组,而pH值与ALB水平均明显高于乙组(P<0.05);甲、乙组中、重度听力障碍比例均明显高于对照组(P<0.05)。乙组重度听力障碍比例明显高于甲组(P<0.05)。甲组与乙组第一次筛查通过率均低于对照组(P<0.05);三组第二次筛查通过率比较,差异无统计学意义(P>0.05)。结论:高胆红素血症对于新生儿听力有一定影响,对高胆红素血症新生儿进行听力筛查可尽早诊断并展开干预治疗,减轻听力障碍风险,具有临床意义。

Objective:To analyze the results of neonatal hearing screening and investigate the effect of hyperbilirubinemia on neonatal hearing.Method:A total of 100 neonates with hyperbilirubinemia admitted to our hospital from June 2016 to June 2019 were selected.According to the total bilirubin value(TBiL),they were divided into group A(220.6μmol/L≤TBiL≤340μmol/L,n=65)and group B(TBiL>340.0μmol/L,n=35).Another 100 full-term normal neonates in our hospital during the same period were selected as the control group.TBiL,pH,serum albumin(ALB)and mean time of jaundice resolution were compared between group A and group B.The severity of hearing impairment and the pass rate of screening were compared among the three groups.Result:The level of TBiL and the mean time of jaundice regression in the group A were lower than those in the group B,while the level of pH and ALB were significantly higher than those in group B(P<0.05).The proportion of moderate and severe hearing impairment in the group A and B were significantly higher than those in the control group(P<0.05).The proportion of severe hearing impairment in the group B was significantly higher than that in group A(P<0.05).The pass rate of the first screening in the group A and B were lower than those in the control group(P<0.05).There was no statistically significant difference in the pass rate of the second screening among the three groups(P>0.05).Conclusion:Hyperbilirubinemia has a certain effect on neonatal hearing.The hearing screening of newborns with hyperbilirubinemia can be diagnosed as soon as possible and intervention treatment can be carried out to reduce the risk of hearing impairment,which has clinical significance.