柴胡疏肝散在肝郁证中的作用机制

Mechanism of Chaihu Shugansan on Syndrome of Liver Stagnation

柴胡疏肝散出自《景岳全书》,是中医疏肝解郁的代表方剂,自明代以来被广泛应用于临床。柴胡疏肝散的疏肝解郁作用通过多成分、多途径、多靶点来实现,目前研究已经从其对神经递质、细胞因子、神经细胞损伤信号通路、神经内分泌、氧化应激等多重作用分别诠释柴胡疏肝散的作用机制。该文总结了柴胡疏肝散的学术渊源、单味药药理、有效作用成分,从心血管系统、神经精神系统、消化系统、生殖相关系统4个方面的临床研究进展进行归纳,对近年来已发表的柴胡疏肝散相关文献进行分析和归纳,探讨柴胡疏肝散在肝郁证中研究的现状和不足之处,并对下一步研究提供思路,在大样本、规范化、临床及实验互相印证方面进行有益探索;结合蛋白质组学研究技术、网络药理学、中药超分子理论等领域,从微观角度把柴胡疏肝散与肝郁证有机相连,将中医学、代谢组学、蛋白质组学、基因组学等多学科综合起来研究,以详细阐明柴胡疏肝散方药、证候、治法及其作用机制。

Chaihu Shugansan is a representative prescription for soothing the liver and relieving depression in traditional Chinese medicine(TCM).Chaihu Shugansan is from Jingyue Quanshu.Chaihu Shugansan has been widely used in clinic since Ming dynasty because of its exact curative effect.Chaihu Shugansan has the effect in soothing the liver and relieving depression through multiple components,multiple ways and multiple targets.At present,the mechanism of Chaihu Shugansan has been interpreted based on its multiple effect on neurotransmitters,cytokines,neuronal injury signal pathways,neuroendocrine,oxidative stress and so on.This paper summarizes the progress of clinical studies on source,pharmacology of single herbs and effective components of Chaihu Shugansan,in aspects of cardiovascular system,neuropsychiatric system,digestive system,reproduction-related systems,analyses and summarizes relevant literatures of Chaihu Shugansan published in recent years,and discusses about current development and shortcomings of Chaihu Shugansan,so as to provide ideas for the studies in the future.Beneficial explorations will be conducted in large-sample-size,standardized,clinical and experimental mutual verification.In proteomics research technology,network pharmacology,supramolecular theory of TCM and other fields,Chaihu Shugansan and liver depression syndrome will be organically connected from the microscopic perspective.And comprehensive studies will be conduct to TCM,metabonomics,proteomics,genomics and other disciplines,in order to clarify Chaihu Shugansan prescriptions,syndromes,therapeutics and its mechanism.