不同声触诊组织成像定量技术在乳腺良恶性结节鉴别诊断中的应用价值

Application value of different virtual touch tissues imaging quantification techniques in the differential diagnosis of benign and malignant breast nodules

目的:探讨声触诊组织定量技术(VTQ)与声触诊组织成像定量技术(VTIQ)在乳腺良恶性结节鉴别诊断中的应用价值。方法:收集乳腺疾病病人58例共58个乳腺实性结节,术前或者穿刺活检前分别应用VTQ、VTIQ技术测量病灶内部剪切波速度值(SWV),与病理结果对照,分别绘制VTQ、VTIQ技术诊断乳腺良恶性结节的ROC曲线,比较2种技术诊断效能。结果:58个乳腺结节中包括恶性结节24个,良性结节34个。VTQ和VTIQ测得乳腺恶性结节的SWV值均明显高于良性结节(P<0.01);对于乳腺良性和恶性结节,VTIQ测得SWV值与VTQ测得差异均无统计学意义(P>0.05)。VTIQ技术ROC曲线下面积为0.820,高于VTQ技术的0.702(P<0.05)。VTQ技术诊断良恶性结节最佳阈值为SWV值3.97 m/s,以3.97 m/s为截断点,其鉴别诊断良恶性结节灵敏度、特异度、准确度依次为66.7%、70.6%、69.0%,AUC为0.702;VTIQ最佳阈值为SWV值4.09 m/s,以4.09 m/s为截断点,其灵敏度、特异度、准确度依次为79.2%、85.3%、82.8%,AUC为0.820。结论:VTIQ技术鉴别诊断乳腺良恶性结节的效能优于VTQ技术,具有较好临床应用前景。

Objective:To explore the application value of virtual touch tissue quantification(VTQ)and virtual touch tissue imaging quantification(VTIQ)in the differential diagnosis of benign and malignant breast nodules.Methods:Fifty-eight breast solid nodules in 58 patients with breast disease were collected.The internal shear wave velocity value(SWV)of the nodules were measured using VTQ and VTIQ techniques before operation or before biopsy,and the results of which were compared with the pathological results.The ROC curve of benign and malignant breast nodules diagnosed by VTQ and VTIQ techniques were drew to compare the diagnostic efficacy of two techniques.Results:Fifty-eight breast nodules included 24 malignant nodules and 34 benign nodules.The mean value of SWV measured by VTQ and VTIQ in malignant nodules was significantly higher than that in benign nodules(P<0.01).For benign and malignant breast nodules,there was no statistical significance in the SWV value measured by VTIQ and VTQ(P>0.05).The area under ROC curve of VTIQ technique(0.820)was higher than that of VTQ technique(0.702)(P<0.05).The best threshold of SWV value in benign and malignant nodules diagnosed by VTQ technique was 3.97 m/s.With 3.97 m/s as cut-off point,the sensitivity,specificity and accuracy of differential diagnosis of benign and malignant nodules were 66.7%,70.6%and 69.0%,respectively,and the AUC was 0.702.The optimal threshold of SWV value diagnosed by VTIQ was 4.09 m/s.With 4.09 m/s as the cut-off point,and the sensitivity,specificity and accuracy were 79.2%,85.3%and 82.8%,respectively,and the AUC was 0.820.Conclusions:The efficacy of VTIQ technique is superior to VTQ in the differential diagnosis of benign and malignant breast nodules,and the VTIQ technique has a better clinical application prospect.