早期糖尿病肾病患者血清TNF-α、IL-6的变化及其与尿白蛋白/肌酐的相关性分析

Changes of Serum TNF-α and IL-6 in Patients with Early Diabetic Nephropathy and Their Correlation with Urinary Albumin/Creatinine

目的:探讨早期糖尿病肾病患者血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)的变化及其与尿白蛋白/肌酐(UACR)的相关性分析。方法:选择2016年12月-2018年12月在本院进行治疗的早期糖尿病肾病患者60例为观察组,选择同期单纯糖尿病患者100例为对照组。两组患者均接受血清TNF-α、IL-6、空腹血糖(FBG)、餐后2 h血糖(2 h PBG)、糖化血红蛋白(HbA1c)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL)及尿白蛋白、尿肌酐检测,并比较上述指标检测结果。结果:两组患者的FBG、2 h PBG、HbA1c、TC、LDL、SBP、DBP比较,差异均无统计学意义(P>0.05);观察组患者血清IL-6、TNF-α、UACR均明显高于对照组,差异均有统计学意义(P<0.05);血清IL-6、TNF-α均与UACR呈正相关(P<0.05)。结论:炎症因子TNF-α、IL-6与早期糖尿病肾病的发生、发展有密切关系。

Objective:To investigate the changes of serum tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in patients with early diabetic nephropathy and their correlation with urinary albumin/creatinine (UACR).Method:A total of 60 patients with early diabetic nephropathy who were treated in our hospital from December 2016 to December 2018 were selected as the observation group.A total of 100 patients with diabetes during the same period were selected as the control group.Serum TNF-α,IL-6,fasting blood glucose (FBG),2-h postpartum blood glucose (2 h PBG),glycated hemoglobin (HbA1c),total cholesterol (TC),low-density lipoprotein cholesterol (LDL),urinary albumin and urinary creatinine were detected in both groups,and compare the results of the above indicators.Result:FBG,2 h PBG,HbA1c,TC,LDL,SBP and DBP were compared between the two groups,the differences were not statistically significant (P>0.05).Serum IL-6,TNF-α and UACR in the observation group were significantly higher than those in the control group,the differences were statistically significant (P<0.05).Serum IL-6 and TNF-α levels were positively correlated with UACR (P<0.05).Conclusion:Inflammatory cytokines TNF-α and IL-6 are closely related to the occurrence and development of early diabetic nephropathy.