川崎病生物学标志物研究进展

Biological markers of Kawasaki disease

川崎病是一种急性自限性血管炎,主要影响婴儿和5岁以下儿童,主要的并发症是冠状动脉病变.约15% ~25%未经治疗的川崎病患儿会留有不同程度的冠状动脉损害.川崎病的发病呈逐年增高趋势,成为儿童后天性心脏病的主要病因之一,对儿童及成年后的生活质量造成严重影响.川崎病的病因尚未明确,近年来已成为儿童心血管病研究的热点问题.随着分子生物学及基因技术的进展,川崎病敏感生物标志物越来越多.该文将对川崎病敏感生物标志物进行综述.

Kawasaki disease is an acute,self-limited vasculitis,which mainly affects infants and children under the age of 5 years.The main complication is coronary artery disease.Untreated Kawasaki disease leads to varying degrees of coronary artery damage in about 15%-25%of patients.The incidence of Kawasaki disease is increasing year by year,which has become one of the main causes of acquired heart disease in children and has a serious impact on the quality of life for children and adults.The cause of Kawasaki disease is not clear.In recent years,it has become a hot topic for pediatric cardiomyovasculopathy.With the development of molecular biology and gene technology,more and more sensitive biomarkers of Kawasaki disease have been found.This article will review the sensitive biomarkers of Kawasaki disease.