病毒性心肌炎免疫机制研究进展

Research progress of the immune pathogenesis of viral myocarditis

病毒性心肌炎发生的病理生理机制尚不完全明确,依然是临床诊断和治疗的巨大的挑战。目前多认为病毒性心肌炎的发展包括两个阶段:病毒感染介导的直接损伤和由免疫反应引起的间接损伤。部分病毒性心肌炎病情迁延可发展为扩张型心肌病,重者可出现心力衰竭、心源性休克甚至猝死。诸多学者认为免疫反应是导致心肌严重损伤的决定性因素。因此,该文将对病毒性心肌炎中免疫发病机制进行综述,旨在为病毒性心肌炎的诊治提供新的理论依据和参考。

There is no consensus regarding pathogenesis of viral myocarditis in pediatric patients.It makes a big challenge in clinical diagnosis and treatment.The myocyte injury is wildly recognized to be initiated by viral proliferation and secondary host immune response.It may persist and lead to dilated cardiomyopathy.In serious cases,it could even end up with heart failure,cardiogenic shock and sudden death.A growing number of scholars consider that host immune response is the main cause of severe cardiomyopathy.This review outlines the current progress of immune response in viral myocarditis,aiming to assist the clinical diagnosis and treatment.