小儿金翘颗粒治疗小儿急性上呼吸道感染的临床研究

Clinical study on Xiao′er Jinqiao Granules in the treatment of children with acute upper respiratory tract infection

目的探讨小儿金翘颗粒治疗小儿急性上呼吸道感染(AURI)的疗效和安全性。方法将门诊收治的240例AURI患儿采用随机数字表法均分为2组:治疗组120例给予小儿金翘颗粒,对照组120例给予复方双花口服液。比较2组患者的临床疗效、主要临床症状改善情况及不良反应发生率,同时比较治疗前后2组血清炎性因子水平及免疫学指标。结果治疗组和对照组的总有效率分别为98.3%和87.5%,治疗组显著高于对照组(P<0.05)。治疗组咽部疼痛、扁桃体充血、发热和全身症状总有效率均显著高于对照组(P<0.05)。治疗组治疗后血清肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)、白介素-8(IL-8)、超敏C-反应蛋白(hs-CRP)及半胱氨酰白三烯(Cysl Ts)水平均显著低于对照组,治疗组CD4+水平及CD4+/CD8+值显著高于对照组,CD8+水平显著低于对照组(P<0.05)。治疗期间2组均出现腹泻、呕吐及恶心,且2组不良反应发生率比较差异无统计学意义。结论小儿金翘颗粒可明显改善AURI患儿的发热和咽喉肿痛等症状,降低AURI患儿的炎症反应及调节免疫功能,且不良反应较少,值得临床推广使用。

Objective To observe the clinical efficacy and safety of Xiao′er Jinqiao Granules in the treatment of children with acute upper respiratory tract infection(AURI).Methods 240 children with AURI were randomly divided into 2 groups:120 cases in the treatment group were given Xiao′er Jinqiao Granules,120 cases in the control group were given Fufang Shuanghua Oral Liquid.The clinical effect,the main clinical symptom improvement and the incidence of adverse reactions were compared between the 2 groups.And the level of serum inflammatory factor and immunological index were compared between the 2 groups before and after treatment.Results The total effective rate was 98.3%in the treatment group and 87.5%in the control group.The total effective rate in the treatment group was significantly higher than that in the control group(P<0.05).The total effective rates of pharynx pain,tonsil congestion,fever and systemic symptoms in the treatment group were significantly higher than those in the control group(P<0.05).The levels of serum tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),interleukin-8(IL-8),high sensitive C-reactive protein(Hs-CRP)and cysteinyl leukotriene(Cysl Ts)in the treatment group were significantly lower than those in the control group after treatment.The levels of CD4+and CD4+/CD8+in the treatment group were significantly higher than those in the control group.The level of CD8+was significantly lower than that of control group(P<0.05).Conclusion Xiao′er Jinqiao Granules can obviously improve the symptoms of fever and throat swelling and pain in children with AURI,reduce inflammatory reaction and regulate immune function in AURI children,and have fewer adverse reactions,so it is worth of popularizing and applying practicing clinic.