血清脂蛋白相关磷脂酶A2和胱抑素C预测急性脑梗死患者溶栓预后分析

Serum Lipoprotein-associated Phospholipase A2 and Cystatin C Predict Prognosis of Thrombolytic Therapy in Patients with Acute Cerebral Infarction

目的:探讨血清脂蛋白相关磷脂酶A2(Lp-PLA2)和胱抑素C(Cys C)预测急性脑梗死患者溶栓预后的价值。方法:选取江门市中心医院60例诊断为急性脑梗死患者作为研究组,同时选取50例健康体检中心非急性脑梗死者作为对照组,比较研究组溶栓前与对照组Lp-PLA2、Cys C水平,近远期不同预后急性脑梗死患者溶栓前Lp-PLA2、Cys C水平,分析Lp-PLA2、Cys C水平对急性脑梗死患者近远期预后预测价值。结果:研究组溶栓前Lp-PLA2、Cys C水平均较对照组显著提高(P<0.05),近期预后不良患者溶栓前Lp-PLA2、Cys C水平均较预后良好患者显著提高(P<0.05),远期预后不良患者溶栓前Lp-PLA2、Cys C水平均较预后良好患者显著提高(P<0.05)。绘制ROC曲线显示,Lp-PLA2、Cys C预测急性脑梗死近期预后的AUC分别为0.958、0.767,预测急性脑梗死远期预后的AUC分别为0.936、0.740。结论:急性脑梗死患者的Lp-PLA2、Cys C水平均显著提高,对该病的早期诊断具有重要意义,且Lp-PLA2预测急性脑梗死近、远期预后价值较高,而Cys C预测价值一般。

Objective:To investigate the value of serum lipoprotein-associated phospholipase A2 (Lp-PLA2) and cystatin C (Cys C) in predicting the prognosis of patients with acute cerebral infarction.Method:Sixty patients diagnosed with acute cerebral infarction in Jiangmen Central Hospital were selected as the study group,and 50 patients with non-acute cerebral infarction in the health check-up center were selected as the control group.The levels of Lp-PLA2 and Cys C in the study group before thrombolysis were compared with those in the control group,the levels of Lp-PLA2 and Cys C in acute cerebral infarction patients before thrombolysis with different prognosis in the short-term and long-term were compared,and the predictive value of Lp-PLA2 and Cys C levels on the short-term and long-term prognosis of patients with acute cerebral infarction were analyzed.Result:The levels of Lp-PLA2 and Cys C before thrombolysis in the study group were significantly higher than those in the control group (P<0.05).The levels of Lp-PLA2 and Cys C before thrombolysis in patients with poor prognosis were significantly higher than those with good prognosis at short-term (P<0.05).The levels of Lp-PLA2 and Cys C before thrombolysis in patients with poor prognosis were significantly higher than those with good prognosis at long-term (P<0.05).The ROC curve was drawn and showed that the AUC of Lp-PLA2 and Cys C to predict the short-term prognosis of acute cerebral infarction were 0.958 and 0.767,respectively.The AUC of predicting the long-term prognosis of acute cerebral infarction were 0.936 and 0.740,respectively.Conclusion:The levels of Lp-PLA2 and Cys C in patients with acute cerebral infarction are significantly increased,which is of great significance for the early diagnosis of the disease,and Lp-PLA2 has a higher value for predicting the short-term and long-term prognosis of acute cerebral infarction,while Cys C has a general value.