重组乙型肝炎疫苗接种剂量与免疫相关因子及隐匿性乙肝感染的关系探究

Investigation on the Relationship between Vaccination Doses of Recombinant Hepatitis B Vaccine and Immune-related Factors,Occult Hepatitis B Infection

目的:探究重组乙型肝炎疫苗接种剂量与免疫相关因子及隐匿性乙肝感染的关系。方法:选取2017年9月-2019年1月的80例重组乙型肝炎疫苗接种者为研究对象,将其根据接种剂量的不同分为A组(10 g,2针组)、B组(10 g,3针组)、C组(20 g,2针组)及D组(20 g,3针组),每组20例。比较四组的抗HBs阳转率、有效保护率及平均几何滴度、相关细胞因子(IL-10、IFN-γ及IL-12)及隐匿性乙肝感染率。结果:C组及D组的抗HBs阳转率、有效保护率及平均几何滴度、相关细胞因子(IL-10、IFN-γ及IL-12)均高于A组及B组,差异均有统计学意义(P<0.05);而C组与D组、A组与B组的上述指标比较,差异均无统计学意义(P>0.05)。四组的隐匿性乙肝感染率比较,差异均无统计学意义(P>0.05)。结论:20 g重组乙型肝炎疫苗接种效果较好,对免疫相关因子的调控作用更好,但对隐匿性乙肝感染无明显影响。

Objective:To investigate the relationship between the dose of recombinant hepatitis B Vaccine and immune-related factors and occult hepatitis B infection.Method:A total of 80 patients receiving recombinant hepatitis B vaccine from September 2017 to January 2019 were selected as study objects.They were divided into group A(10 g,2 needles),group B(10 g,3 needles),group C(20 g,2 needles)and group D(20 g,3 needles)according to the inoculation dose,20 cases in each group.HBs positive rate,effective protection rate,mean geometric titer,related cytokines(IL-10,IFN-γand IL-12),and occult hepatitis B infection rate were compared among the four groups.Result:The positive rate of HBs resistance,effective protection rate,mean geometric titer and related cytokines(IL-10,IFN-γand IL-12)in group C and group D were higher than those in group A and group B,all the differences were statistically significant(P<0.05).The above indexes of group C and group D,group A and group B were compared,there were no significant differences(P>0.05).Compared the occult hepatitis B infectior of four groups,the differences were no significant differences(P>0.05).Conclusion:The effect of 20 g recombinant hepatitis B Vaccine is better,the regulation of immune related factors is better,but there is no significant effect on the occult hepatitis B infection.