缺血修饰白蛋白和脂蛋白磷脂酶A2联合检测对缺血性脑卒中病情评估价值

The Value of Combined Detection of Ischemic Modified Albumin and Lipoprotein Phospholipase A2 in Evaluating Ischemic Stroke

目的:探讨缺血修饰白蛋白(IMA)和脂蛋白磷脂酶A2(Lp-PLA2)联合检测对缺血性脑卒中病情评估价值。方法:选取2017年1月-2019年8月本院收治的缺血性脑卒中患者68例作为缺血性脑卒中组,并选取同期本院接受健康体检的健康者68例作为对照组,比较两组实验室相关指标水平及阳性表达率,比较缺血性脑卒中组Lp-PLA2与IMA表达阳性与阴性者心电图(ECG)异常发生率。结果:缺血性脑卒中组合并原发性高血压比例高于对照组(P<0.05);缺血性脑卒中组Lp-PLA2、IMA、同型半胱氨酸(Hcy)、脂蛋白(a)[Lp(a)]及超敏C反应蛋白(hs-CRP)水平均高于对照组(P<0.05);缺血性脑卒中组Lp-PLA2、IMA、Hcy、Lp(a)及hs-CRP阳性表达率均高于对照组(P<0.05);缺血性脑卒中组Lp-PLA2与IMA表达阳性者ECG异常发生率均高于阴性者(P<0.05)。结论:缺血性脑卒中患者Lp-PLA2、IMA水平升高,且Lp-PLA2、IMA表达阳性的患者ECG异常发生率明显升高,可以通过对Lp-PLA2、IMA水平检测评估缺血性脑卒中患者病情及预后。

Objective:To investigate the evaluation value of combined detection of ischemia-modified albumin(IMA)and lipoprotein phospholipase A2(Lp-PLA2)in ischemic stroke.Method:A total of 68 cases of ischemic stroke patients admitted to our hospital from January 2017 to August 2019 were selected as the ischemic stroke group.The total of 68 cases of healthy patients receiving physical examination in our hospital during the same period were selected as the control group.The levels of relevant indicators and positive expression rates in the two groups were compared,and the incidence of electrocardiogram(ECG)abnormalities in Lp-PLA2 and IMA positive and negative expressions in the ischemic stroke group were compared.Result:The proportion of patients with essential hypertension in the ischemic stroke group was higher than that in the control group(P<0.05).The levels of Lp-PLA2,IMA,homocysteine(Hcy),lipoprotein(a)[Lp(a)]and hypersensitive C-reactive protein(hs-CRP)in the ischemic stroke group were higher than those in the control group(P<0.05).The positive expression rates of Lp-PLA2,IMA,Hcy,Lp(a)and hs-CRP in the ischemic stroke group were higher than those in the control group(P<0.05).The incidence of ECG abnormalities in the ischemic stroke group with Lp-PLA2 and IMA positive expression were higher than those with negative expression(P<0.05).Conclusion:Lp-PLA2 and IMA levels are increased in patients with ischemic stroke.The incidence of ECG abnormalities in patients with Lp-PLA2 and IMA positive expression was significantly increased.Lp-PLA2 and IMA levels can be used to evaluate the condition and prognosis of patients with ischemic stroke.