TSP-1和TGF-β1在妊娠期糖尿病胎盘组织中的意义及与胎儿缺氧的关系

The Significance of TSP-1 and TGF-β1 in the Placental Tissues of Gestational Diabetes Mellitus and Their Relationship with Fetal Hypoxia

目的:探讨血小板反应蛋白1(TSP-1)和转化生长因子β1(TGF-β1)在妊娠期糖尿病(gestational diabetes mellitus,GDM)胎盘组织中的意义及与胎儿缺氧的关系。方法:选取本院2019年1-8月的40例GDM孕妇作为观察组,并选取同期40例正常孕妇作为对照组。所有孕妇分娩时留取胎盘组织。比较两组TSP-1和TGF-β1表达阳性率;比较观察组TSP-1、TGF-β1表达阳性与阴性者的血糖指标;分析TSP-1和TGF-β1表达与GDM孕妇血糖指标的相关性,比较观察组TSP-1和TGF-β1表达阳性与阴性者的胎儿缺氧发生率。结果:观察组TSP-1与TGF-β1表达阳性率均高于对照组(P<0.05)。观察组TSP-1与TGF-β1阳性者的空腹血糖、糖化血红蛋白及胰岛素抵抗指数(HOMA-IR)均高于阴性者(P<0.05)。TSP-1与TGF-β1表达与空腹血糖、糖化血红蛋白、HOMA-IR均呈正相关(P<0.05)。观察组TSP-1与TGF-β1表达阳性者的胎儿缺氧发生率均高于阴性者(P<0.05)。结论:GDM孕妇胎盘组织中TSP-1和TGF-β1表达阳性率较高,TSP-1和TGF-β1表达与空腹血糖、糖化血红蛋白及HOMA-IR均呈正相关,TSP-1和TGF-β1表达阳性会增加胎儿缺氧风险。

Objective:To investigate the significance of thrombospondins-1(TSP-1)and transforming growth factorβ1(TGF-β1)in the placental tissues of gestational diabetes mellitus(GDM)and their relationship with fetal hypoxia.Method:A total of 40 pregnant women with GDM in our hospital from January to August 2019 were selected as the observation group,and 40 normal pregnant women in the same period were selected as the control group.Placental tissue was collected from all pregnant women at the time of delivery.The positive expression rates of TSP-1 and TGF-β1 in the two groups were compared.The blood glucose indexes of the patients with positive and negative expression of TSP-1 and TGF-β1 in the observation group were compared.To analyze the correlation between the expression of TSP-1 and TGF-β1 and the blood glucose index in pregnant women with GDM,and the incidence of fetal hypoxia in the patients with positive and negative expression of TSP-1 and TGF-β1 in the observation group were compared.Result:The positive rate of expression of TSP-1 and TGF-β1 in the observation group were higher than those in the control group(P<0.05).Fasting glucose,glycosylated hemoglobin and insulin resistance index(HOMA-IR)of patients with positive expression of TSP-1 and TGF-β1 in the observation group were higher than those with negative(P<0.05).The expression of TSP-1 and TGF-β1 was positively correlated with fasting blood glucose,glycosylated hemoglobin and HOMA-IR(P<0.05).The incidence of fetal hypoxia in the patients with positive expression of TSP-1 and TGF-β1 in the observation group was higher than negative(P<0.05).Conclusion:The positive rate of expression of TSP-1 and TGF-β1 in the placental tissues of pregnant women with GDM was higher,the expression of TSP-1 and TGF-β1 was positively correlated with fasting blood glucose,glycosylated hemoglobin and HOMA-IR,and positive expression of TSP-1 and TGF-β1 increased the risk of fetal hypoxia.