血清类风湿因子、C反应蛋白、免疫球蛋白检测在类风湿关节炎诊断中的应用及临床意义

The Application and Clinical Significance of Detection of Serum Rheumatoid Factor, C-reactive Protein and Immunoglobulin in the Diagnosis of Rheumatoid Arthritis

目的:研究血清类风湿因子、C反应蛋白、免疫球蛋白检测在类风湿关节炎诊断中的应用及临床意义。方法:选取2017年12月-2018年10月本院收治的类风湿关节炎患者40例为研究组,选取同期来本院行健康体检的人群30例为对照组。两组均使用同样的方法检测血清类风湿因子水平、C反应蛋白水平及免疫球蛋白水平。观察比较两组类风湿因子、C反应蛋白及免疫球蛋白水平差异;并比较研究组治疗前后的类风湿因子、C反应蛋白及免疫球蛋白水平变化情况。结果:研究组类风湿因子水平及C反应蛋白水平均显著高于对照组,差异均有统计学意义(P<0.05)。研究组免疫球蛋白IgA、IgG及IgM水平均显著低于对照组,差异均有统计学意义(P<0.05)。治疗后,研究组的类风湿因子水平及C反应蛋白水平均低于治疗前,免疫球蛋白IgA、IgG及IgM水平均高于治疗前,差异均有统计学意义(P<0.05)。结论:类风湿关节炎患者进行临床诊断的过程中,检测血清类风湿因子、C反应蛋白及免疫球蛋白水平,可辅助提高临床对类风湿关节炎的诊断有效率,方便对类风湿关节炎进行及时诊疗,可有效预防发生进一步的损害。

Objective: To study the application and clinical significance of detection of serum rheumatoid factor, C-reactive protein and immunoglobulin in the diagnosis of rheumatoid arthritis. Method: A total of 40 patients with rheumatoid arthritis admitted to our hospital from December 2017 to October 2018 were selected as the study group. A total of 30 patients who underwent physical examination in the same period were selected as the control group. Serum rheumatoid factor levels, C-reactive protein levels and immunoglobulin levels were measured using the same method in both groups. The levels of rheumatoid factor, C-reactive protein and immunoglobulin in the two groups were compared. The changes of rheumatoid factor, C-reactive protein and immunoglobulin before and after treatment were compared in the study group. Result: The levels of rheumatoid factor and C-reactive protein in the study group were significantly higher than those in the control group, with statistically significant differences(P<0.05). IgA, IgG and IgM levels of immunoglobulin in the study group were significantly lower than those in the control group, with statistically significant differences(P<0.05). After treatment, the levels of rheumatoid factor and C-reactive protein in the study group were lower than those before treatment, IgA, IgG and IgM levels of immunoglobulin were higher than those before treatment, the differences were statistically significant(P<0.05). Conclusion: During the clinical diagnosis of rheumatoid arthritis patients, the detection of serum rheumatoid factor, C-reactive protein and immunoglobulin levels can help improve the clinical diagnosis efficiency of rheumatoid arthritis, convenient for rheumatoid arthritis timely diagnosis and treatment, can effectively prevent the occurrence of further damage.