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基于肠道微生态角度探讨中医药治疗社区获得性肺炎的作用机制 被引量:7

Discussion on the mechanism of TCM treatment of community-acquired pneumonia based on intestinal microecology
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摘要 社区获得性肺炎(CAP)属于呼吸科临床上常见病范畴。近年来随着对肠道菌群发病机制的深入研究,越来越多的证据显示肠道菌群与宿主的共生关系是人体健康的重要保障,其中CAP的发生发展与肠道微生物生态系统的紊乱息息相关。肠道菌群失调会造成肠源性内毒素和炎症介质的释放影响肺,反之,CAP产生的急性肺部炎症也会扰乱肠道微生物群。本文旨在探讨肠道微生态与CAP的相关性,以及基于中医理论“整体观念、肺与大肠相表里”探讨中医药调节肠道菌群治疗CAP的可能性及作用机制,以期发挥中医药治疗优势,用中西医结合的方法为CAP的治疗提供新的思路。 Community-acquiredpneumonia(CAP)is a common respiratory disease.In recent years,along with the deep research in the pathogenesis of intestinal flora,more and more evidence indicates that the symbiotic relationship between intestinal flora and host is an important guarantee for human health,in which the development of CAP is closely related with the disorders of intestinal microbial ecosystem.Intestinal flora imbalance can cause the release of intestinal endotoxin and inflammatory mediators,on the other hand,acute lung inflammation caused by CAP can also disrupt the intestinal microbiota.The purpose of this paper is to explore the correlation between intestinal microecology and CAP,and to explore the possibility and mechanism of TCM in regulating intestinal tract flora in the treatment of CAP based on TCM theory“integrated concept,interior-exterior relationship between lung and large intestin”,so as to give full play to the advantages of TCM treatment and provide a new idea for the treatment of CAP with the method of integrated Chinese and western medicine.
作者 刘兴慈 苏克雷 张业清 朱梦月 刘茜 曹亚坤 何孔琴 LIU Xingci;SU Kelei;ZHANG Yeqing;ZHU Mengyue;LIU Qian;CAO Yakun;HE Kongqin(The Third Clinical Medical College,Nanjing University of Chinese Medicine,Jiangsu Province,Nanjing210023,China;Respiratory Department,Affiliated Hospital of Integrated Traditional Chinese and Western Medicine,Nanjing University of Chinese Medicine,Jiangsu Province,Nanjing210028,China)
出处 《中国医药导报》 CAS 2020年第7期39-42,共4页 China Medical Herald
基金 江苏省研究生培养创新工程研究生科研与实践创新计划项目(SJCX19_0384)。
关键词 肠道微生态 社区获得性肺炎 中医药 作用机制 Intestinal microecology Community-acquired pneumonia Traditional Chinese medicine Mechanism
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