摘要
目的探讨下肢动脉硬化闭塞症(PAD)患者经加味阳和汤治疗后的临床效果。方法选取辽宁省辽阳市中医院2017年3月~2019年3月收治的133例PAD患者根据随机数字表法将其分为研究组(67例,常规西医联合加味阳和汤治疗)和对照组(66例,常规西医治疗)。比较两组患者临床疗效、不良反应、中医证候积分、血液流变学指标及踝肱指数(ABI)、足背动脉血流量、间歇性跛行距离情况。结果治疗后研究组临床总有效率高于对照组(P<0.05)。治疗1个月后两组中医证候积分以及全血高切黏度、血浆黏度、血细胞比容、红细胞聚集指数均较治疗前降低,且研究组低于对照组(P<0.05)。治疗1个月后两组ABI、足背动脉血流量、间歇性跛行距离均较治疗前升高,且研究组高于对照组(P<0.05)。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论加味阳和汤治疗PAD,可迅速改善患者临床症状,疗效确切,可改善机体血液循环,用药安全性较好。
Objective To investigate the clinical effect of Jiawei Yanghe Decoction treating peripheral arterial disease(PAD).Methods A total of 133 PAD patients in Liaoyang Hospital of Traditional Chinese Medicine were selected from March 2017 to March 2019 and they were divided into the study group(67 cases,conventional western medicine combined with Jiawei Yanghe Decoction)and the control group(66 cases,conventional western medicine)according to the random number table method.The clinical efficacy,adverse reactions,traditional Chinese medition syndrome score,hemorheology indexes and ankle brachial index(ABI),blood flow of dorsalis pedis artery and intermittent claudication distance of patients in the two groups were compared.Results After treatment the total clinical effective rate of the study group was higher than that of the control group(P<0.05).After 1 month of treatment,the traditional Chinese medition syndrome scores and high blood viscosity,plasma viscosity,hematocrit,red cell assembling index in the two groups were all lower than before treatment,and the study group was lower than the control group(P<0.05).After 1 month of treatment,the ABI,blood flow of dorsalis pedis artery,intermittent claudication distance were increased in the two groups,and the study group was higher than the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Jiawei Yanghe Decoction can rapidly improve the clinical symptoms of patients with PAD,with definite curative effect,and also can improve the blood circulation of the body,with good drug safety.
作者
代丹丹
隋文林
李美彧
DAI Dandan;SUI Wenlin;LI Meiyu(Drug Manufacturing Room,Liaoyang Hospital of Traditional Chinese Medicine,Liaoning Province,Liaoyang111000,China;Department of Geriatrics,Liaoyang Hospital of Traditional Chinese Medicine,Liaoning Province,Liaoyang111000,China)
出处
《中国医药导报》
CAS
2020年第7期152-155,共4页
China Medical Herald
基金
辽宁省科学技术研究发展计划项目(C20160067)。
关键词
下肢动脉硬化闭塞症
加味阳和汤
血液流变学
疗效
Peripheral Arterial Disease
Jiawei Yanghe Decoction
Hemorheology
Curative effect