托吡酯联合丙戊酸钠用于难治性癫痫治疗中的效果评价

Evaluation of the effect of topiramate combined with sodium valproate in the treatment of intractable epilepsy

目的:探究托吡酯联合丙戊酸钠用于难治性癫痫治疗中的效果。方法:2017年1月-2019年2月收治难治性癫痫患者106例,随机分为两组,各53例。单一组给予丙戊酸钠治疗;联合组采用托吡酯联合丙戊酸钠治疗。比较两组患者治疗后癫痫发作次数,炎性因子水平,疗效和不良反应。结果:联合组治疗后患者癫痫强直-阵挛发作、失神发作、失张力发作次数、炎性因子水平、不良反应发生率均少于单一组,治疗总有效率高于单一组,差异均有统计学意义(P<0.05)。结论:托吡酯联合丙戊酸钠治疗难治性癫痫效果显著,安全性较高,能有效降低炎性因子水平,减少癫痫发作次数。

Objective:To explore the effect of topiramate combined with sodium valproate in the treatment of intractable epilepsy.Methods:106 patients with intractable epilepsy were selected from January 2017 to February 2019,they were randomly divided into the two groups with 53 cases in each group.The single group was given sodium valproate,the combined group was treated with topiramate and sodium valproate.The frequency of epileptic seizures,the level of inflammatory factors,the efficacy and adverse reactions were compared between the two groups.Results:The frequency of epileptic tonic clonic attack,absence seizure,atonic seizure,the level of inflammatory factors and the incidence of adverse reactions in the combined group were lower than those in the single group,the total effective rate of treatment was higher than that of single group,the difference was statistically significant(P<0.05).Conclusion:Topiramate combined with sodium valproate is effective in the treatment of refractory epilepsy,with high safety,and can effectively reduce the level of inflammatory factors and reduce the number of seizures.