丁苯酞治疗大动脉粥样硬化型脑梗死的临床效果及对总有效率影响分析

Clinical effect of butylphthalide in the treatment of atherosclerotic cerebral infarction and its influence on the total effective rate

目的:研究丁苯酞治疗大动脉粥样硬化型脑梗死的临床效果及对总有效率的影响。方法:本次纳入2014年1月至2018年12月收治的80例大动脉粥样硬化型脑梗死患者,按照随机数字表法分为两组,对照组40例予以长春西汀治疗,观察组40例加用丁苯酞治疗。对两组患者的神经功能缺损评分、日常生活活动能力评分、颈动脉斑块情况、临床疗效、不良反应发生情况进行比对。结果:观察组患者治疗后的NIHSS评分以及最大斑块面积、内膜中层厚度、斑块数量均低于对照组,治疗后的Barthel指数、临床总有效率均高于对照组,差异有统计学意义(P<0.05);两组患者的不良反应发生率进行比较,差异无统计学意义(P>0.05)。结论:在大动脉粥样硬化型脑梗死患者治疗中采用丁苯酞具有较高的有效性和安全性,有助于改善患者的神经功能以及日常生活活动能力,阻止颈动脉斑块持续进展,临床应用价值高。

Objective:To study the clinical effect of butylphthalide in the treatment of atherosclerotic cerebral infarction and its effect on the total effective rate.Methods:80 patients with large atherosclerotic cerebral infarction(from January 2014 to December 2018)were enrolled in this study.They were divided into two groups according to random number table method.40 patients in the control group were treated with vinpocetine,and the other 40 patients in the observation group were treated with butylphthalide.The neurological deficit score,activity of daily living score,arterial plaque,clinical efficacy and adverse reactions were compared between the two groups.Results:The NIHSS score,maximum plaque area,intima-media thickness and number of plaques in the observation group after treatment were lower than those in the control group.The Barthel index and total clinical effective rate after treatment were higher than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Butylphthalide is effective and safe in the treatment of patients with atherosclerotic cerebral infarction.It is helpful to improve the neurological function and activities of daily life,prevent the continuous progress of atherosclerotic plaque,and has high clinical value.