艾司洛尔在急性非ST段抬高型心肌梗死中早期应用的疗效及安全性探究

The study of effects and safety of esmolol in the early stage of non-ST segment elevation myocardial infarction

目的:探讨艾司洛尔在急性非ST段抬高型心肌梗死早期应用的疗效及安全性。方法:选取2016年6月-2018年8月我院收治的急性非ST段抬高型心肌梗死患者143例,随机分为观察组(静脉泵入艾司洛尔+口服β受体阻滞剂)64例和对照组(常规口服β受体阻滞剂)79例,比较两组治疗前后胸痛缓解情况、心电图ST段恢复程度及其并发症的情况。结果:观察组总有效率为89.1%,对照组为73.4%,差异有统计学意义(P<0.05)。治疗前,两组的ST段压低水平无统计学差异(P>0.05);治疗后,两组ST段均有不同程度的恢复,观察组恢复程度更大(P<0.05),对照组不良反应事件较观察组多,但差异无统计学意义(P>0.05)。结论:艾司洛尔在急性非ST段抬高型心肌梗死中早期应用疗效显著,安全可靠。

Objective:To explore the effeet and and safety of esmolol in the early stage of non-ST segment elevation myocardial infarction.Methods:143 patients,from June 2016 to August 2018 of our hospital with non ST segment elevation myocardial infarction,were randomly divided 64 cases(intravenous pumping esmolol+oral beta-adrenergic receptor blockers)into observation group,79 cases(normal beta-adrenergic receptor blockers)into control group,compared two groups before and after treatment of chest pain relief situation of ECG ST segment recovery degree and its complications.Results:The total effective rate was 89.1%in the observation group and 73.4%in the control group,with statistical significance(P<0.05).Before treatment,there was no significant difference in ST segment depression between the two groups(P>0.05).After treatment,ST segment recovery was observed in both groups to different degrees,with greater recovery in the observation group(P<0.05),and more adverse reaction events in the control group than those in the observation group,but the difference was not statistically significant(P>0.05).Conclusions:esmolol is safe and effective in the early stage of acute non-ST elevation myocardial infarction.