自身免疫性肝炎自身抗体的研究进展

Research advances in autoantibodies in autoimmune hepatitis

自身抗体对自身免疫性肝炎(AIH)的诊断、分型和鉴别诊断具有重要的价值。但AIH的自身抗体存在缺乏疾病特异性、种类多且检测结果不一致等问题,给临床诊断带来困惑。基于文献数据和笔者临床经验,对AIH的主要自身抗体应用价值和研究进展、相关指南对自身抗体检测方法的推荐意见等进行简单介绍。

Autoantibodies have an important value in the diagnosis,typing,and differential diagnosis of autoimmune hepatitis(AIH);however,the autoantibodies of AIH lack specificity and have various types and inconsistent results,which brings confusions to clinical diagnosis.With reference to the literature data and the author’s clinical experience,this article reviews the application value and research advances in the main autoantibodies in AIH and introduces the recommendations for autoantibody detection methods in related guidelines.