28例亳州市新型冠状病毒肺炎患者肝损伤的特征分析

Features of liver injury in patients with coronavirus disease 2019 in Bozhou,China

目的探讨不同人群2019冠状病毒病(COVID-2019)患者肝损伤情况,进一步了解COVID-2019的致病特点。方法纳入2020年2月1日-2月12日亳州市COVID-2019定点收治医院确诊为COVID-2019伴有肝损伤的28例患者。按照性别和年龄分为男性组(n=15)和女性组(n=13)、青年组(n=10)和中老年组(n=17),检测入院时患者ALT、AST、GGT、ALP和乳酸脱氢酶(LDH)的水平。计量资料两组间比较采用Wilcoxon秩和检验,计数资料两组间比较采用Fisher确切检验。结果28例患者出现不同程度的肝损伤,ALT、AST、GGT、ALP和LDH水平在男性组和女性组、青年组和中老年组间差异均无统计学意义(P值均>0.05)。男性组与女性组的ALT、AST、GGT和LDH指标异常率差异均无统计学意义(P值均>0.05);青年组和中老年组的ALT、AST、GGT指标异常率差异均无统计学意义(P值均>0.05),但LDH指标异常率差异有统计学意义(P<0.05)。结论COVID-2019患者随着病情的发展会出现不同程度的肝损伤,在轻型及普通型患者中肝损伤与性别及年龄无明显相关性。因此,对COVID-2019患者应注意监测肝功能的变化,慎重选择治疗方法以防肝损伤。

Objective To investigate the condition of liver injury in different populations of patients with coronavirus disease 2019(COVID-2019),and to further understand the pathogenic characteristics of COVID-2019.Methods A total of 28 patients with COVID-2019 and liver injury who were admitted to the designated hospitals for COVID-2019 in Bozhou,China from February 1 to 12,2020 were enrolled,and they were divided into male group(n=15)and female group(n=13)according to sex or young group(n=10)and middle-aged and elderly group(n=17)according to age.The levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST),gamma-glutamyl transpeptidase(GGT),alkaline phosphatase(ALP),and lactate dehydrogenase(LDH)were measured on admission.The Wilcoxon rank-sum test was used for comparison of continuous data between two groups,the Fisher exact test was used for comparison of categorical data between two groups.Results Varying degrees of liver injury were observed in the 28 patients.There were no significant differences in the levels of ALT,AST,GGT,ALP,and LDH between the male group and the female group and between the young group and the middle-aged and elderly group(all P>0.05).There was no significant difference in abnormal rate of ALT,AST,GGT and LDH between male group and female group(all P>0.05);There was no significant difference in abnormal rate of ALT,AST,GGT between the young group and the middle-aged and elderly group(all P>0.05);there was a significant difference in abnormal rate of LDH between the young group and the middle-aged and elderly group(P<0.05).Conclusion Patients with COVID-2019 may experience different degrees of liver injury with the development of the disease,middle-aged and elderly patients tend to develop liver injury.There was no significant correlation with gender and age in mild and general patients.Therefore,liver function should be monitored in patients with COVID-2019,and the treatment method should be selected carefully to prevent liver injury.