STAT3:慢性炎症介导肝癌进程的关键分子

STAT3:A key molecule in the progression of liver cancer mediated by chronic inflammation

STAT3是信号转导及转录激活因子家族成员,在肝癌等慢性炎症相关性肿瘤中异常激活。作为肝癌炎症微环境中的关键信号分子,STAT3不仅参与肝癌发生过程中的“炎癌转化”,而且通过多种方式促进肝癌进展中癌细胞的增殖、侵袭与转移,是一个潜在的肝癌治疗靶标。综述了近几年STAT3与肝癌关系的新进展。

STAT3,a member of the signal transducer and activator of transcription family,is abnormally activated in chronic inflammation-related tumors including liver cancer.As a key signal molecule in the microenvironment of liver cancer and inflammation,STAT3 not only participates in the inflammation-cancer transformation during the development of liver cancer,but also promotes the proliferation,invasion,and metastasis of hepatoma cells through many ways,and therefore,it may be a potential target for the treatment of liver cancer.This article reviews the recent advances in the association between STAT3 and liver cancer.