中期18 F-FDG PET-CT在滤泡淋巴瘤预后评估中的价值

Value of interim 18 F-FDG PET-CT in prognosis evaluation of follicular lymphoma

目的:探讨滤泡性淋巴瘤(FL)患者治疗4周期后(中期)18 F-FDG PET-CT在预后评估中的价值。方法:回顾性分析经病理确诊且行中期PET-CT检查的FL患者43例,采用Deauville 5分法判读中期PET-CT结果,其中1~3分判定为PET-CT阴性,≥4分为阳性。采用Cox风险比例回归模型分析中期PET-CT对FL患者预后的评估价值。结果:中期PET-CT阳性18例,阴性25例,两组患者一般临床特征比较,差异无统计学意义(P>0.05)。随访时间15~69(中位数36)个月。Cox回归分析结果显示,中期PET-CT阳性预示FL患者总生存、无进展生存时间缩短,预后不良,HR(95%CI)为5.436(1.357~21.783)、4.142(1.588~10.807)。结论:中期PET-CT对FL的预后评估具有一定的临床应用价值。

Aim:To explore the role of 18 F-FDG PET-CT after 4-cycle treatment(mid-term PET-CT)in prognosis evaluation of follicular lymphoma(FL).Methods:Forty-three FL patients diagnosed pathologically were retrospectively analyzed.Deauville 5 score method was used to interpret the results of PET-CT(1-3 score was negative,and≥4 score was positive).Cox proportional hazards regression model was used to analyze the value of mid-term PET-CT for predicting the prognosis of FL.Results:Follow-up period was 15-69(median=36)months.The mid-term PET-CT was negative in 25 patients and positive in 18 patients.There was no statistical difference between the positive and negative PET-CT groups in the general clinical characteristics of FL patients(P>0.05).Cox regression results showed that mid-term PET-CT positive was the predictor of adverse outcomes for FL,and HR(95%CI)based on OS and PFS was 5.436(1.357-21.783),4.142(1.588-10.807).Conclusion:Mid-term PET-CT is of values in evaluating the prognosis of FL.