急性脑梗死患者血清溶血磷脂酸、胱抑素-C水平与颈动脉斑块稳定性的相关性分析

The correlation between levels of serum LPA and Cys-C and carotid plaque stability in patients with acute cerebral infarction

目的探讨急性脑梗死(ACI)患者血清溶血磷脂酸(LPA)、胱抑素-C(Csy-C)水平与其颈动脉斑块稳定性的相关性。方法我院收治的97例ACI患者,根据患者颈动脉斑块性质,分为无斑块组(n=17)、稳定性斑块组(n=33)与非稳定性斑块组(n=47),比较三组一般资料、常规实验室检查结果及血清LPA及Cys-C水平,分析影响患者颈动脉斑块稳定性的因素。结果无斑块组、稳定斑块组及不稳定斑块组患者年龄呈依次上升趋势(P<0.05),三组性别、BMI、糖尿病史、高血压病史、吸烟史及饮酒史比较,差异无统计学意义(P>0.05);无斑块组、稳定斑块组及不稳定斑块组间LPA、Cys-C、CRP及Hcy水平均呈依次上升趋势(P<0.05),三组LDL、HDL及TG水平比较,差异无统计学意义(P>0.05);年龄、血清LPA、Cys-C水平及LDL、CRP水平均是影响颈动脉斑块稳定性的危险因素(P<0.05);随颈动脉IMT增加,急性脑卒中患者血清LPA及Cys-C水平均呈依次上升趋势(P<0.05)。结论ACI患者血清LPA及Cys-C水平与颈动脉斑块形成、稳定性间具有紧密关联,可通过血清LPA、Cys-C水平预测患者颈动脉斑块性质与预后。

Objective To investigate the correlation between levels of serum lysophosphatidic acid(LPA)and cystatin-C(Csy-C)and carotid plaque stability in patients with acute cerebral infarction(ACI).Methods We selected 97 patients with ACI admitted to our hospital in this study.According to the nature of carotid plaque,they were divided into non-plaque group(n=17),stable plaque group(n=33)and unstable plaque group(n=47).The general data,routine laboratory examination results and levels of serum LPA and Cys-C were compared among the three groups,and the factors affecting carotid plaque stability were analyzed.Results The ages of patients were increased in turn from the non-plaque group,the stable plaque group to the unstable plaque group(P<0.05).There was no significant differences in the gender,BMI,history of diabetes,hypertension,smoking and drinking among the three groups(P>0.05).The levels of LPA,Cys-C,CRP and Hcy in the non-plaque group,the stable plaque group and the unstable plaque group were also increased in turn(P<0.05).There were no significant differences in the levels of LDL,HDL and TG among the three groups(P>0.05).Logistic regression analysis showed that age,serum LPA,Cys-C and LDL and CRP were risk factors affecting carotid plaque stability(P<0.05).With the increase of carotid intima-media thickness,the levels of serum LPA and Cys-C in patients with acute stroke were increased(P<0.05).Conclusion Levels of serum LPA and Cys-C in ACI patients are closely related to carotid plaque formation and stability.The characteristics and prognosis of carotid plaque can be predicted by using serum LPA and Cys-C levels.