细胞程序性坏死参与冠心病病程的研究进展

Research progress of cell necroptosis involved in the course of CHD

程序性坏死(Necroptosis)是近年来新提出的一种受到精密调控的细胞死亡方式,在细胞凋亡受到抑制时启动,由受体配体介导且呈现坏死样结构特点。在参与Necroptosis过程的众多因子中,RIP1和RIP3是通路必不可少的信号传递蛋白,MLKL是下游的关键因子,介导下游级联反应。Necroptosis在炎症过程、氧化应激、肿瘤增殖等疾病生理发展中发挥重要作用。近年来,随着各种心血管疾病发病率逐年增高,程序性坏死在心血管疾病中的表达及调控成为研究热点,本文就冠心病的疾病发展过程中Necroptosis的作用进行简要概述。

Necroptosis is a new cell death mode which is regulated by precision regulation in recent years.It is initiated when apoptosis is inhibited,and is mediated by receptor ligand and characterized by death-like structure.Among the many factors involved in the process of Necroptosis,RIP1 and RIP3 are essential signal transduction proteins,and MLKL is the key downstream factor,which mediates down-cascade reaction.Necroptosis plays an important role in the physiological development of inflammation,oxidative stress,tumor proliferation and other diseases.In recent years,with the increasing incidence of various cardiovascular diseases,the expression and regulation of programmed necrosis in cardiovascular diseases has become a hot topic.The role of Necroptosis in the development of coronary heart disease is briefly summarized in this paper.