软坚消瘿颗粒联合左甲状腺素钠片治疗桥本甲状腺炎伴甲状腺功能减退临床疗效

Clinical effect of Ruanjianxiaoying granules combined with levothyroxine sodium tablets in the treatment of Hashimoto's thyroiditis with hypothyroidism

目的探讨软坚消瘿颗粒联合左甲状腺素钠片治疗桥本甲状腺炎伴甲状腺功能减退的临床疗效。方法选取2018年1—9月于北部战区总医院门诊就诊的120例桥本甲状腺炎伴甲状腺功能减退患者为研究对象。采用随机数字表法将患者分为常规组与观察组,每组各60例。常规组给予口服左甲状腺素钠片治疗,观察组给予口服软坚消瘿颗粒联合左甲状腺素钠片治疗。两组连续给药6个月后,比较两组患者治疗前后中医症候疗效、甲状腺功能[血清游离三碘甲状腺原氨酸(FT3)、血清游离甲状腺素(FT4)、血清促甲状腺素(TSH)]及甲状腺相关抗体水平[甲状腺过氧化物酶抗体(TPOAb)、甲状腺球蛋白抗体(TgAb)]的差异。结果观察组治疗有效率为93.3%(56/60),高于常规组的51.7%(31/60),差异有统计学意义(P<0.05)。两组治疗后TSH、FT3、FT4、TPOAb、TgAb水平均优于各组治疗前,差异有统计学意义(P<0.05);且治疗后,观察组的TSH、FT4、TPOAb、TgAb水平优于常规组,差异有统计学意义(P<0.05)。结论软坚消瘿颗粒联合左甲状腺素钠片治疗桥本甲状腺炎伴甲状腺功能减退临床疗效显著。

Objective To investigate the clinical effect of Ruanjianxiaoying granules combined with levothyroxine sodium tablets in the treatment of hashimoto's thyroiditis with hypothyroidism.Methods A retrospective study was performed on 120 cases of patients with Hashimoto's thyroiditis and hypothyroidism who were admitted from January to September 2018.The patients were randomly divided into the conventional group and the observation group,with 60 cases in each group.The conventional group was treated with oral levothyroxine sodium tablets,while the observation group was treated with oral Ruanjianxiaoying granules combined with levothyroxine sodium tablets.Continuous dosing after six months,the two groups to compare two groups of patients before and after treatment of TCM symptoms curative effect,thyroid function[three iodine in serum free thyroid glycine(FT3),serum free thyroxine(FT4),serum thyroid stimulating hormone(TSH)]and thyroid related antibody levels of thyroid peroxidase antibodies(TPOAb)and thyroglobulin(TgAb).Results The effective rate in the observation group was 93.3%(56/60),higher than that in the conventional group(51.7%,31/60),and the difference was statistically significant(P<0.05).The TSH,FT3,FT4,TPOAb and TgAb levels of the two groups after treatment were all better than those before treatment(P<0.05).After treatment,TSH,FT4,TPOAb and TgAb levels in the observation group were better than those in the conventional group(P<0.05).Conclusion The clinical effect of Ruanjianxiaoying granules combined with levothyroxine sodium tablets in the treatment of Hashimoto's thyroiditis with hypothyroidism is significant.