IKBKE和FOXO3在结直肠癌中的表达及临床意义分析

Expression of IKBKE and FOXO3 in colorectal cancer and their clinicopathological significances

目的探讨结直肠癌组织中核因子κB激酶亚单位ε抑制剂(IKBKE)和叉头框蛋白O3(FOXO3)的表达及与临床病理特征和生存预后的关系。方法应用免疫组织化学染色方法检测该院2013年1月至2014年1月79例结直肠癌组织中IKBKE和FOXO3的表达,分析其临床意义。结果结直肠癌组织中IKBKE的表达与结直肠癌患者的性别、年龄及肿瘤浸润深度无关(P>0.05),与分化程度、TNM分期及有无淋巴结转移相关(P<0.05)。结直肠癌组织中FOXO3的表达与结直肠癌患者的性别、年龄及肿瘤浸润深度无关(P>0.05),与分化程度、TNM分期及有无淋巴结转移相关(P<0.05)。IKBKE与FOXO3表达呈负相关(P<0.01,r=-0.41)。生存曲线及Cox回归模型显示,IKBKE与FOXO3作为结直肠癌患者的独立预后危险因素均不确切(P>0.05)。结论联合检测IKBKE和FOXO3在结直肠癌组织中的表达,有助于判断结直肠癌的恶性程度及转移潜能。

Objective To detect the expression of nuclear factor-κB kinase subunitεinhibitor(IKBKE)and forkhead box protein O3(FOXO3)in colorectal cancer tissue,and to explore their correlation with clinicopathological features and survival prognosis.Methods Immunohistochemisty was used to detect the expression of IKBKE and FOXO3 in 79 patients with colorectal infection from January 2013 to January 2014 in this hospital,for analysis of their clinical significances.Results The expression of IKBKE was not correlated with gender,age or depth of tumor invasion in patients with colorectal cancer(P>0.05),and associated with differentiation,TNM stage and lymph node metastasis(P<0.05).The expression of FOXO3 was not correlated with gender,age or depth of tumor invasion in patients with colorectal cancer(P>0.05),and associated with differentiation,TNM stage and lymph node metastasis(P<0.05).There was a negative correlation between IKBKE and FOXO3 expression(P<0.01,r=-0.41).Survival curve and Cox regression model showed that IKBKE and FOXO3 were not accurate as independent prognostic risk factors for colorectal cancer patients(P>0.05).Conclusion Combined detection of expressions of IKBKE and FOXO3 in colorectal cancer tissue is helpful to determine the malignant degree and metastatic potential of colorectal cancer.