膀胱癌患者血清miR-144水平及其临床意义分析

Serum miR-144 and its clinical significance in patients with bladder cancer

目的探讨膀胱癌患者血清miR-144水平及其临床意义。方法选择该院2014年1月至2015年12月膀胱癌患者140例作为观察组,同期体检健康者140例作为对照组,测定两组血清miR-144、CA125水平。结果观察组患者血清miR-144低于对照组(P<0.05),CA125水平高于对照组(P<0.05)。膀胱癌患者血清miR-144水平与肿瘤分期、淋巴结转移相关(P<0.05),与性别、年龄、肿瘤大小、肿瘤分级无明显相关(P>0.05)。血清miR-144、CA125水平及二者联合诊断膀胱癌的ROC曲线下面积分别为0.829、0.781、0.851。miR-144低表达组3年总生存率低于miR-144高表达组(χ^2=5.347,P=0.007)。结论膀胱癌患者血清miR-144水平降低,其在膀胱癌严重程度和预后评估中具有一定价值,可提高CA125诊断膀胱癌的准确性。

Objective To investigate the level of serum miR-144 in patients with bladder cancer and its clinical significance.Methods A total of 140 patients with bladder cancer were selected as the observation group and 140 healthy patients underwent physical examination were selected as the control group from January 2014 to December 2015 in the hospital.The levels of serum miR-144 and CA125 were detected.Results The level of serum miR-144 in the observation group was lower than that in the control group(P<0.05),and the level of serum CA125 was higher than that in the control group(P<0.05).The level of serum miR-144 were closely related to tumor stage and lymph node metastasis in bladder cancer patients(P<0.05),and had no significant correlation with gender,age,tumor size and tumor grade(P>0.05).The area under the ROC curve of serum miR-144,CA125 levels and combination of them for diagnosis of bladder cancer were 0.829,0.781 and 0.851,respectively.The 3-year overall survival rate of the miR-144 low-expression group was lower than that of the miR-144 high-expression group(χ^2=5.347,P=0.007).Conclusion Serum miR-144 decreased in patient with bladder cancer,which has a certain value in the assessment of severity and prognosis for bladder cancer,and it could improve the accuracy of CA125 in the diagnosis of bladder cancer.